About: Catecholamine and insulin control of lipolysis in subcutaneous adipose tissue during long-term diet-induced weight loss in obese women     Goto   Sponge   NotDistinct   Permalink

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Description
  • The aim of this study was to investigate the evolution of the adrenergic and insulin-mediated regulation of lipolysis during different phases of a 6-mo dietary intervention. Eight obese women underwent a 6-mo dietary intervention consisting of a 1-mo very low-calorie diet (VLCD) followed by a 2-mo low-calorie diet (LCD) and 3-mo weight maintenance (WM) diet. At each phase of the dietary intervention, microdialysis of subcutaneous adipose tissue (SCAT) was performed at rest and during a 3-h hyperinsulinemic euglycemic clamp. Responses of dialysate glycerol concentration (DGC) were determined at baseline and during local perfusions with adrenaline or adrenaline and phentolamine before and during the last 30 min of the clamp. Dietary intervention induced a body weight reduction and an improved insulin sensitivity. DGC progressively decreased during the clamp, and this decrease was similar during the different phases of the diet.
  • The aim of this study was to investigate the evolution of the adrenergic and insulin-mediated regulation of lipolysis during different phases of a 6-mo dietary intervention. Eight obese women underwent a 6-mo dietary intervention consisting of a 1-mo very low-calorie diet (VLCD) followed by a 2-mo low-calorie diet (LCD) and 3-mo weight maintenance (WM) diet. At each phase of the dietary intervention, microdialysis of subcutaneous adipose tissue (SCAT) was performed at rest and during a 3-h hyperinsulinemic euglycemic clamp. Responses of dialysate glycerol concentration (DGC) were determined at baseline and during local perfusions with adrenaline or adrenaline and phentolamine before and during the last 30 min of the clamp. Dietary intervention induced a body weight reduction and an improved insulin sensitivity. DGC progressively decreased during the clamp, and this decrease was similar during the different phases of the diet. (en)
Title
  • Catecholamine and insulin control of lipolysis in subcutaneous adipose tissue during long-term diet-induced weight loss in obese women
  • Catecholamine and insulin control of lipolysis in subcutaneous adipose tissue during long-term diet-induced weight loss in obese women (en)
skos:prefLabel
  • Catecholamine and insulin control of lipolysis in subcutaneous adipose tissue during long-term diet-induced weight loss in obese women
  • Catecholamine and insulin control of lipolysis in subcutaneous adipose tissue during long-term diet-induced weight loss in obese women (en)
skos:notation
  • RIV/00216208:11120/12:00003199!RIV12-MZ0-11120___
http://linked.open...avai/riv/aktivita
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  • P(NS10519), P(NT11450), R
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  • 2
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http://linked.open...aciTvurceVysledku
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  • 126132
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  • RIV/00216208:11120/12:00003199
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  • alpha2-adrenergic responsiveness; adrenaline; glycerol; microdialysis; dietary intervention (en)
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  • US - Spojené státy americké
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  • [B40E73D911EC]
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  • American Journal of Physiology - Endocrinology and Metabolism
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  • 302
http://linked.open...iv/tvurceVysledku
  • Polák, Jan
  • Šiklová-Vítková, Michaela
  • Štich, Vladimír
  • Klimčáková, Eva
  • Koppo, Katrien
http://linked.open...ain/vavai/riv/wos
  • 000299112700008
issn
  • 0193-1849
number of pages
http://bibframe.org/vocab/doi
  • 10.1152/ajpendo.00240.2011
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  • 11120
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