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Description
  • Systemic inflammation involves powerful immune response that interferes with homeostatic regulation of many physiological processes including those controlling appetite and nutritional balance. In advanced chronic diseases, such as chronic obstructive pulmonary disease (COPD), rheumatoid arthritis, chronic infection or sepsis, renal failure, heart failure and cancer, the immune response is frequently exaggerated insofar as it ultimately leads to a severe debilitating state known as cachexia. It is well known that this condition deteriorates the quality of life and predicts increased morbidity and mortality. According to a recent definition, cachexia is characterized as a complex metabolic syndrome associated with a loss of body weight. In this condition, inflammation, anorexia, insulin resistance and increased muscle protein breakdown are present and result in depletion of skeletal muscle with or without a loss of fat mass (Evans et al., 2008). These hallmarks considerably distinguish cachexia from ot
  • Systemic inflammation involves powerful immune response that interferes with homeostatic regulation of many physiological processes including those controlling appetite and nutritional balance. In advanced chronic diseases, such as chronic obstructive pulmonary disease (COPD), rheumatoid arthritis, chronic infection or sepsis, renal failure, heart failure and cancer, the immune response is frequently exaggerated insofar as it ultimately leads to a severe debilitating state known as cachexia. It is well known that this condition deteriorates the quality of life and predicts increased morbidity and mortality. According to a recent definition, cachexia is characterized as a complex metabolic syndrome associated with a loss of body weight. In this condition, inflammation, anorexia, insulin resistance and increased muscle protein breakdown are present and result in depletion of skeletal muscle with or without a loss of fat mass (Evans et al., 2008). These hallmarks considerably distinguish cachexia from ot (en)
Title
  • Cachexia - The Interplay Between the Immune System, Brain Control and Metabolism
  • Cachexia - The Interplay Between the Immune System, Brain Control and Metabolism (en)
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  • Cachexia - The Interplay Between the Immune System, Brain Control and Metabolism
  • Cachexia - The Interplay Between the Immune System, Brain Control and Metabolism (en)
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  • RIV/00216208:11120/12:00002990!RIV12-MSM-11120___
http://linked.open...avai/riv/aktivita
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  • Z(MSM0021620816)
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  • 125777
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  • RIV/00216208:11120/12:00002990
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  • inflammatory diseases; cachexia; cytokines; anorexia; insulin resistance; muscle catabolism (en)
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  • [83C5B78E88D5]
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  • Inflammatory Diseases - Immunopathology, Clinical and Pharmacological Bases [On-line]
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  • Štofková, Andrea
http://linked.open...n/vavai/riv/zamer
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  • InTech
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  • 978-953-307-911-0
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  • 11120
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