About: Low numbers and altered phenotype of invariant natural killer T cells in recurrent varicella zoster virus infection

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About: Low numbers and altered phenotype of invariant natural killer T cells in recurrent varicella zoster virus infection Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1016/j.cellimm.2011.04.008
Description	Invariant natural killer T (iNKT) cells play an important role in the immune response against various infectious agents. In this study we investigated their role in human defense against the varicella zoster virus. We observed decreased numbers of iNKT cells in patients who failed to control latent varicella zoster virus infection, e.g. underwent several reactivations of the virus. The residual population of iNKT cells expressed significantly higher levels of inhibitory receptor CD158a that was further up-regulated in the course of acute viral infection. Both of these abnormalities might contribute to impaired control of varicella zoster virus in human Invariant natural killer T (iNKT) cells play an important role in the immune response against various infectious agents. In this study we investigated their role in human defense against the varicella zoster virus. We observed decreased numbers of iNKT cells in patients who failed to control latent varicella zoster virus infection, e.g. underwent several reactivations of the virus. The residual population of iNKT cells expressed significantly higher levels of inhibitory receptor CD158a that was further up-regulated in the course of acute viral infection. Both of these abnormalities might contribute to impaired control of varicella zoster virus in human (en)
Title	Low numbers and altered phenotype of invariant natural killer T cells in recurrent varicella zoster virus infection Low numbers and altered phenotype of invariant natural killer T cells in recurrent varicella zoster virus infection (en)
skos:prefLabel	Low numbers and altered phenotype of invariant natural killer T cells in recurrent varicella zoster virus infection Low numbers and altered phenotype of invariant natural killer T cells in recurrent varicella zoster virus infection (en)
skos:notation	RIV/00216208:11120/11:00003327!RIV12-MSM-11120___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM0021620814)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Novák, Jan Nováková, Lucie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	210016
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/11:00003327
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	iNKT cells; varicella zoster virus; NK cells; natural killer receptors (en)
http://linked.open.../riv/klicoveSlovo	NK cells iNKT cells natural killer receptors varicella zoster virus
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[FF4688BA1279]
http://linked.open...i/riv/nazevZdroje	Cellular Immunology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	269
http://linked.open...iv/tvurceVysledku	Novák, Jan Nováková, Lucie Lehuen, Agnes
http://linked.open...ain/vavai/riv/wos	000291765300003
http://linked.open...n/vavai/riv/zamer	Prevention, diagnostics and therapy of diabetes mellitus, metabolic and endocrine damage of organism
issn	0008-8749
number of pages	4 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.cellimm.2011.04.008
http://localhost/t...ganizacniJednotka	11120

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