About: Modulations of behavioral consequences of minor cortical ischemic lesion by application of free radicals scavengers

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About: Modulations of behavioral consequences of minor cortical ischemic lesion by application of free radicals scavengers Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.4149/gpb_2011_03_263
Description	Functional and morphological consequences of ischemic lesions are partially related to the production of reactive oxygen species (ROS). The aim of the study was to create a unilateral photothrombic lesion with minimal morphological changes and minor sensorimotor and cognitive deficits and also to test whether the application of ROS scavengers after the end of induction of ischemia had improved the functional outcome. Adult Wistar male rats were randomly divided into five groups: naive control, sham operated animals, animals with induced ischemia, and two groups of animals with induced ischemia and subsequent ROS scavenger application - melatonin or tempol. The group subjected to ischemia showed a significant decline in performance in sensorimotor tests and the Morris water maze (MWM) test, compared to control animals. Tempol (50 mg/kg, i.p.) did not improve sensorimotor function and did not change spatial learning. Melatonin (100 mg/kg, i.p.), on the contrary, resulted in a significant improvement in Functional and morphological consequences of ischemic lesions are partially related to the production of reactive oxygen species (ROS). The aim of the study was to create a unilateral photothrombic lesion with minimal morphological changes and minor sensorimotor and cognitive deficits and also to test whether the application of ROS scavengers after the end of induction of ischemia had improved the functional outcome. Adult Wistar male rats were randomly divided into five groups: naive control, sham operated animals, animals with induced ischemia, and two groups of animals with induced ischemia and subsequent ROS scavenger application - melatonin or tempol. The group subjected to ischemia showed a significant decline in performance in sensorimotor tests and the Morris water maze (MWM) test, compared to control animals. Tempol (50 mg/kg, i.p.) did not improve sensorimotor function and did not change spatial learning. Melatonin (100 mg/kg, i.p.), on the contrary, resulted in a significant improvement in (en)
Title	Modulations of behavioral consequences of minor cortical ischemic lesion by application of free radicals scavengers Modulations of behavioral consequences of minor cortical ischemic lesion by application of free radicals scavengers (en)
skos:prefLabel	Modulations of behavioral consequences of minor cortical ischemic lesion by application of free radicals scavengers Modulations of behavioral consequences of minor cortical ischemic lesion by application of free radicals scavengers (en)
skos:notation	RIV/00216208:11120/11:00003239!RIV12-MSM-11120___
http://linked.open...avai/riv/aktivita	S Z
http://linked.open...avai/riv/aktivity	S, Z(MSM0021620816)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Schutová, Barbora Pometlová, Marie Deykun, Kateryna Mareš, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	213437
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/11:00003239
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cortical ischemia; cognitive impairment; behavior; ROS scavenger (en)
http://linked.open.../riv/klicoveSlovo	ROS scavenger cortical ischemia behavior cognitive impairment
http://linked.open...odStatuVydavatele	SK - Slovenská republika
http://linked.open...ontrolniKodProRIV	[99A87350E545]
http://linked.open...i/riv/nazevZdroje	General Physiology and Biophysics
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	30
http://linked.open...iv/tvurceVysledku	Mareš, Jan Pometlová, Marie Schutová, Barbora Deykun, Kateryna
http://linked.open...ain/vavai/riv/wos	000295655800004
http://linked.open...n/vavai/riv/zamer	Název: Patofyziologie neuropsychiatrických onemocnění a její klinické aplikace
issn	0231-5882
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.4149/gpb_2011_03_263
http://localhost/t...ganizacniJednotka	11120

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