About: Does prenatal methamphetamine exposure affect the drug-seeking behavior of adult male rats?

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1016/j.bbr.2011.05.021
Description	Methamphetamine (MA) is one of the most frequently used illicit drugs worldwide and also one of the most common drugs abused by pregnant women. Repeated administration of psychostimulants induces behavioral sensitization in response to treatment of the same or related drugs in rodents. The effect of prenatal MA exposure on sensitivity to drugs in adulthood is not yet fully determined. Because our most recent studies demonstrated that prenatal MA (5 mg/kg) exposure makes adult rats more sensitive to acute injection of the same drug, we were interested whether the increased sensitivity corresponds with the increased drug-seeking behavior. The aim of the present study was to examine the effect of prenatal MA exposure on drug-seeking behavior of adult male rats tested in the conditioned place preference (CPP). The following psychostimulant drugs were used as a challenge in adulthood: MA (5 mg/kg), amphetamine (5 mg/kg) and cocaine (10 mg/kg). Methamphetamine (MA) is one of the most frequently used illicit drugs worldwide and also one of the most common drugs abused by pregnant women. Repeated administration of psychostimulants induces behavioral sensitization in response to treatment of the same or related drugs in rodents. The effect of prenatal MA exposure on sensitivity to drugs in adulthood is not yet fully determined. Because our most recent studies demonstrated that prenatal MA (5 mg/kg) exposure makes adult rats more sensitive to acute injection of the same drug, we were interested whether the increased sensitivity corresponds with the increased drug-seeking behavior. The aim of the present study was to examine the effect of prenatal MA exposure on drug-seeking behavior of adult male rats tested in the conditioned place preference (CPP). The following psychostimulant drugs were used as a challenge in adulthood: MA (5 mg/kg), amphetamine (5 mg/kg) and cocaine (10 mg/kg). (en)
Title	Does prenatal methamphetamine exposure affect the drug-seeking behavior of adult male rats? Does prenatal methamphetamine exposure affect the drug-seeking behavior of adult male rats? (en)
skos:prefLabel	Does prenatal methamphetamine exposure affect the drug-seeking behavior of adult male rats? Does prenatal methamphetamine exposure affect the drug-seeking behavior of adult male rats? (en)
skos:notation	RIV/00216208:11120/11:00003172!RIV12-MZ0-11120___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA305/09/0126), P(NS10509), Z(MSM0021620816)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Schutová, Barbora Pometlová, Marie Hrubá, Lenka Šlamberová, Romana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	195192
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/11:00003172
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Amphetamine; Cocaine; Conditioned place preference; Drug-seeking behavior; Methamphetamine; Prenatal drug exposure (en)
http://linked.open.../riv/klicoveSlovo	Cocaine Amphetamine Conditioned place preference Drug-seeking behavior Methamphetamine Prenatal drug exposure
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[BB974389778A]
http://linked.open...i/riv/nazevZdroje	Behavioural Brain Research
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Does prenatal methamphetamine exposure induce cross-sensitization to drugs in adult male and female rats? Active drug-seeking behavior in prenatally methamphetamine-exposed adult male and female rats
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	224
http://linked.open...iv/tvurceVysledku	Hrubá, Lenka Pometlová, Marie Schutová, Barbora Šlamberová, Romana
http://linked.open...ain/vavai/riv/wos	000293312200011
http://linked.open...n/vavai/riv/zamer	Název: Patofyziologie neuropsychiatrických onemocnění a její klinické aplikace
issn	0166-4328
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.bbr.2011.05.021
http://localhost/t...ganizacniJednotka	11120

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