About: Increased seizure susceptibility induced by prenatal methamphetamine exposure in adult female rats is not affected by early postnatal cross-fostering

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About: Increased seizure susceptibility induced by prenatal methamphetamine exposure in adult female rats is not affected by early postnatal cross-fostering Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1016/j.yebeh.2010.10.009
Description	Our previous studies repeatedly demonstrated that prenatal methamphetamine (MA) exposure alters seizure susceptibility in adult rats. Both the inhibitory GABA system and the excitatory NMDA system play a role in the effect of MA on epileptic seizures. On the basis of our previous behavioral results, the effect of cross-fostering on seizure susceptibility in adult female rats was examined in the present study. Bicuculline (GABAA receptor antagonist) and NMDA (NMDA receptor agonist) were used to induce seizures in adult female offspring exposed to MA in the prenatal and/or preweaning periods. Female dams were injected with MA (5mg/kg daily) or physiological saline (S) for approximately 9weeks [about 3weeks prior to impregnation, for the entire gestation period (22days), and in the preweaning period (21days)]. Absolute controls (C) did not receive any injections. On postnatal day 1, pups were cross-fostered so that each mother received pups from all three treatments. Our previous studies repeatedly demonstrated that prenatal methamphetamine (MA) exposure alters seizure susceptibility in adult rats. Both the inhibitory GABA system and the excitatory NMDA system play a role in the effect of MA on epileptic seizures. On the basis of our previous behavioral results, the effect of cross-fostering on seizure susceptibility in adult female rats was examined in the present study. Bicuculline (GABAA receptor antagonist) and NMDA (NMDA receptor agonist) were used to induce seizures in adult female offspring exposed to MA in the prenatal and/or preweaning periods. Female dams were injected with MA (5mg/kg daily) or physiological saline (S) for approximately 9weeks [about 3weeks prior to impregnation, for the entire gestation period (22days), and in the preweaning period (21days)]. Absolute controls (C) did not receive any injections. On postnatal day 1, pups were cross-fostered so that each mother received pups from all three treatments. (en)
Title	Increased seizure susceptibility induced by prenatal methamphetamine exposure in adult female rats is not affected by early postnatal cross-fostering Increased seizure susceptibility induced by prenatal methamphetamine exposure in adult female rats is not affected by early postnatal cross-fostering (en)
skos:prefLabel	Increased seizure susceptibility induced by prenatal methamphetamine exposure in adult female rats is not affected by early postnatal cross-fostering Increased seizure susceptibility induced by prenatal methamphetamine exposure in adult female rats is not affected by early postnatal cross-fostering (en)
skos:notation	RIV/00216208:11120/11:00002423!RIV12-GA0-11120___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0517), P(GAP303/10/0580), Z(MSM0021620816)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Hrubá, Lenka Šlamberová, Romana Matějovská, Iveta Bernášková, Klára Rokyta, Richard
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	204112
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/11:00002423
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Bicuculline; Cross-fostering; Methamphetamine; N-methyl-D-aspartic acid; Seizures (en)
http://linked.open.../riv/klicoveSlovo	Bicuculline Cross-fostering N-methyl-D-aspartic acid Seizures Methamphetamine
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[954492985DEA]
http://linked.open...i/riv/nazevZdroje	Epilepsy & Behavior
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of Neuropsychiatric Studies 2005-2009 (Neurobiology in Clinical Application) What is the role of mesolimbic reward circuit in the long-term effect of prenatal methamphetamine exposure in rats?
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	20
http://linked.open...iv/tvurceVysledku	Hrubá, Lenka Rokyta, Richard Šlamberová, Romana Bernášková, Klára Matějovská, Iveta
http://linked.open...ain/vavai/riv/wos	000287331300002
http://linked.open...n/vavai/riv/zamer	Název: Patofyziologie neuropsychiatrických onemocnění a její klinické aplikace
issn	1525-5050
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.yebeh.2010.10.009
http://localhost/t...ganizacniJednotka	11120

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