About: Perinatal effect of methamphetamine on nociception in adult Wistar rats

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1016/j.ijdevneu.2010.08.004
Description	Methamphetamine is a psychostimulant drug which causes the release of monoamine neurotransmitters. Although drugs of abuse are known to have analgesic effects, there is a lack of evidence regarding the effect of prenatal exposure to methamphetamine on nociception in adulthood. Adult Wistar rats whose mothers had received daily exposure to methamphetamine (5 mg/kg; s.c.) or saline, during gestation or gestation and lactation periods, were examined for: (1) gender differences in nociception; (2) an association between nociception and gross-motor behavior in the plantar test; (3) effects of cross-fostering on nociception; and (4) analgesic effects of an acute injection of methamphetamine (1 mg/kg s.c.). Nociception was tested using the plantar test on postnatal days 85-90. Prenatal methamphetamine increased sensitivity to pain on forelimbs (p < 0.0001) and hind limbs (p < 0.05) in females only. Methamphetamine is a psychostimulant drug which causes the release of monoamine neurotransmitters. Although drugs of abuse are known to have analgesic effects, there is a lack of evidence regarding the effect of prenatal exposure to methamphetamine on nociception in adulthood. Adult Wistar rats whose mothers had received daily exposure to methamphetamine (5 mg/kg; s.c.) or saline, during gestation or gestation and lactation periods, were examined for: (1) gender differences in nociception; (2) an association between nociception and gross-motor behavior in the plantar test; (3) effects of cross-fostering on nociception; and (4) analgesic effects of an acute injection of methamphetamine (1 mg/kg s.c.). Nociception was tested using the plantar test on postnatal days 85-90. Prenatal methamphetamine increased sensitivity to pain on forelimbs (p < 0.0001) and hind limbs (p < 0.05) in females only. (en)
Title	Perinatal effect of methamphetamine on nociception in adult Wistar rats Perinatal effect of methamphetamine on nociception in adult Wistar rats (en)
skos:prefLabel	Perinatal effect of methamphetamine on nociception in adult Wistar rats Perinatal effect of methamphetamine on nociception in adult Wistar rats (en)
skos:notation	RIV/00216208:11120/11:00002415!RIV12-GA0-11120___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0517), P(GA305/09/0126), P(LC554), Z(MSM0021620816)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Schutová, Barbora Hrubá, Lenka Šlamberová, Romana Rokyta, Richard Yamamotová, Anna
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	219939
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/11:00002415
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	analgesia; gender differences; methamphetamine; nociception; stress (en)
http://linked.open.../riv/klicoveSlovo	gender differences methamphetamine stress analgesia nociception
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[577BF920BCD7]
http://linked.open...i/riv/nazevZdroje	International Journal of Developmental Neuroscience
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of Neuropsychiatric Studies 2005-2009 (Neurobiology in Clinical Application) Neuroscience Centre Does prenatal methamphetamine exposure induce cross-sensitization to drugs in adult male and female rats?
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	29
http://linked.open...iv/tvurceVysledku	Hrubá, Lenka Rokyta, Richard Schutová, Barbora Šlamberová, Romana Yamamotová, Anna
http://linked.open...ain/vavai/riv/wos	000286846500012
http://linked.open...n/vavai/riv/zamer	Název: Patofyziologie neuropsychiatrických onemocnění a její klinické aplikace
issn	0736-5748
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.ijdevneu.2010.08.004
http://localhost/t...ganizacniJednotka	11120

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