About: Worsening of obesity and metabolic status yields similar molecular adaptations in human subcutaneous and visceral adipose tissue: Decreased metabolism and increased immune response

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About: Worsening of obesity and metabolic status yields similar molecular adaptations in human subcutaneous and visceral adipose tissue: Decreased metabolism and increased immune response Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1210/jc.2010-1575
Description	It is not known whether biological differences reported between sc adipose tissue (SAT) and visceral adipose tissue (VAT) depots underlie the pathogenicity of visceral fat. We compared SAT and VAT gene expression according to obesity, visceral fat accumulation, insulin resistance, and presence of the metabolic syndrome. Subjects were assigned into four groups (lean, overweight, obese, and obese with metabolic syndrome). Subjects were recruited at a university hospital. Thirty-two women were included. Anthropometric measurements, euglycemic-hyperinsulinemic clamps, blood analyses, and computed tomography scans were performed, and paired samples of SAT and VAT were obtained for DNA microarray-based gene expression profiling. Considering the two fat depots together, 1125 genes were more and 1025 genes were less expressed in lean compared with metabolic syndrome subjects. It is not known whether biological differences reported between sc adipose tissue (SAT) and visceral adipose tissue (VAT) depots underlie the pathogenicity of visceral fat. We compared SAT and VAT gene expression according to obesity, visceral fat accumulation, insulin resistance, and presence of the metabolic syndrome. Subjects were assigned into four groups (lean, overweight, obese, and obese with metabolic syndrome). Subjects were recruited at a university hospital. Thirty-two women were included. Anthropometric measurements, euglycemic-hyperinsulinemic clamps, blood analyses, and computed tomography scans were performed, and paired samples of SAT and VAT were obtained for DNA microarray-based gene expression profiling. Considering the two fat depots together, 1125 genes were more and 1025 genes were less expressed in lean compared with metabolic syndrome subjects. (en)
Title	Worsening of obesity and metabolic status yields similar molecular adaptations in human subcutaneous and visceral adipose tissue: Decreased metabolism and increased immune response Worsening of obesity and metabolic status yields similar molecular adaptations in human subcutaneous and visceral adipose tissue: Decreased metabolism and increased immune response (en)
skos:prefLabel	Worsening of obesity and metabolic status yields similar molecular adaptations in human subcutaneous and visceral adipose tissue: Decreased metabolism and increased immune response Worsening of obesity and metabolic status yields similar molecular adaptations in human subcutaneous and visceral adipose tissue: Decreased metabolism and increased immune response (en)
skos:notation	RIV/00216208:11120/11:00002396!RIV12-MZ0-11120___
http://linked.open...avai/riv/aktivita	P R
http://linked.open...avai/riv/aktivity	P(NS10519), R
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Klimčáková, Eva Kováčiková, Michaela Hejnová, Jindřiška Štich, Vladimír Kováčová, Zuzana Šiklová-Vítková, Michaela Šrámková, Petra
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	241919
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/11:00002396
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Gene-Expression; Macrophage Infiltration; Insulin Sensitivity; Body-Fat; Adipocytes; Inflammation; Secretion; Transplantation (en)
http://linked.open.../riv/klicoveSlovo	Secretion Adipocytes Body-Fat Gene-Expression Insulin Sensitivity Macrophage Infiltration Inflammation Transplantation
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[7A8DD5EF0F06]
http://linked.open...i/riv/nazevZdroje	Journal of Clinical Endocrinology and Metabolism
http://linked.open...in/vavai/riv/obor	FB
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	13 (xsd:int)
http://linked.open...vavai/riv/projekt	Relative abundance of macrophages and other cell populations in adipose tissue in relation to obesity and associated metabolic complications
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	96
http://linked.open...iv/tvurceVysledku	Kováčová, Zuzana Šiklová-Vítková, Michaela Štich, Vladimír Hejnová, Jindřiška Klimčáková, Eva Kováčiková, Michaela Šrámková, Petra
http://linked.open...ain/vavai/riv/wos	000288185400009
issn	0021-972X
number of pages	12 (xsd:int)
http://bibframe.org/vocab/doi	10.1210/jc.2010-1575
http://localhost/t...ganizacniJednotka	11120

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