About: Mycophenolate mofetil vs azathioprine for remission maintenance in antineutrophil cytoplasmic antibody-associated vasculitis: a randomized controlled trial     Goto   Sponge   NotDistinct   Permalink

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Description
  • Current remission maintenance therapies for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) are limited by partial efficacy and toxicity. To compare the effects of mycophenolate mofetil with azathioprine on the prevention of relapses in patients with AAV. Design, Setting, and Participants Open-label randomized controlled trial, International Mycophenolate Mofetil Protocol to Reduce Outbreaks of Vasculitides (IMPROVE), to test the hypothesis that mycophenolate mofetil is more effective than azathioprine for preventing relapses in AAV. The trial was conducted at 42 centers in 11 European countries between April 2002 and January 2009 (42-month study). Eligible patients had newly diagnosed AAV (Wegener granulomatosis or microscopic polyangiitis) and were aged 18 to 75 years at diagnosis.
  • Current remission maintenance therapies for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) are limited by partial efficacy and toxicity. To compare the effects of mycophenolate mofetil with azathioprine on the prevention of relapses in patients with AAV. Design, Setting, and Participants Open-label randomized controlled trial, International Mycophenolate Mofetil Protocol to Reduce Outbreaks of Vasculitides (IMPROVE), to test the hypothesis that mycophenolate mofetil is more effective than azathioprine for preventing relapses in AAV. The trial was conducted at 42 centers in 11 European countries between April 2002 and January 2009 (42-month study). Eligible patients had newly diagnosed AAV (Wegener granulomatosis or microscopic polyangiitis) and were aged 18 to 75 years at diagnosis. (en)
Title
  • Mycophenolate mofetil vs azathioprine for remission maintenance in antineutrophil cytoplasmic antibody-associated vasculitis: a randomized controlled trial
  • Mycophenolate mofetil vs azathioprine for remission maintenance in antineutrophil cytoplasmic antibody-associated vasculitis: a randomized controlled trial (en)
skos:prefLabel
  • Mycophenolate mofetil vs azathioprine for remission maintenance in antineutrophil cytoplasmic antibody-associated vasculitis: a randomized controlled trial
  • Mycophenolate mofetil vs azathioprine for remission maintenance in antineutrophil cytoplasmic antibody-associated vasculitis: a randomized controlled trial (en)
skos:notation
  • RIV/00216208:11120/10:00003106!RIV12-MSM-11120___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • N, V
http://linked.open...iv/cisloPeriodika
  • 21
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
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  • 273325
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  • RIV/00216208:11120/10:00003106
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Systemic Necrotizing Vasculitis; Lupus Nephritis; Wegeners-Granulomatosis; Renal Involvement; Acute Rejection; Vessel Vasculitis; Clinical-Trial; Long-Term; Cyclophosphamide; Induction (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [E51F4EEC96A1]
http://linked.open...i/riv/nazevZdroje
  • JAMA-Journal of the American Medical Association
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
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http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 304
http://linked.open...iv/tvurceVysledku
  • Rychlík, Ivan
  • Hiemstra, T. F.
http://linked.open...ain/vavai/riv/wos
  • 000284763900019
issn
  • 0098-7484
number of pages
http://bibframe.org/vocab/doi
  • 10.1001/jama.2010.1658
http://localhost/t...ganizacniJednotka
  • 11120
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