About: Changes in cytokine concentrations following successful ablation of atrial fibrillation

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Atrial fibrillation is associated with the activation of inflammatory processes [e.g. higher concentrations of pro-inflammatory cytokines interleukin-6 (IL-6), C-reactive protein (CRP)], as well as a pro-thrombotic state [e.g. increased concentration of serum pro-thrombotic markers P-selectin and CD40 ligand (CD40L)]. The aim of the present study was to establish, whether successful epicardial ablation of AF leads to decreased concentrations of traditional inflammatory and thrombotic markers. Twenty-five patients with symptomatic paroxysmal or persistent AF were prospectively studied. All underwent epicardial isolation of pulmonary veins. The success of the ablation was assessed clinically and with three Holter recordings. Blood samples were drawn before, three and six months after surgery. Serum concentrations of IL-6, interleukin-10 (IL-10), CRP, CD40L and P-selectin were measured using ELISA. AF was successfully ablated in 15 patients (SR group). In the other 10 patients (AF group), AF re-occurred Atrial fibrillation is associated with the activation of inflammatory processes [e.g. higher concentrations of pro-inflammatory cytokines interleukin-6 (IL-6), C-reactive protein (CRP)], as well as a pro-thrombotic state [e.g. increased concentration of serum pro-thrombotic markers P-selectin and CD40 ligand (CD40L)]. The aim of the present study was to establish, whether successful epicardial ablation of AF leads to decreased concentrations of traditional inflammatory and thrombotic markers. Twenty-five patients with symptomatic paroxysmal or persistent AF were prospectively studied. All underwent epicardial isolation of pulmonary veins. The success of the ablation was assessed clinically and with three Holter recordings. Blood samples were drawn before, three and six months after surgery. Serum concentrations of IL-6, interleukin-10 (IL-10), CRP, CD40L and P-selectin were measured using ELISA. AF was successfully ablated in 15 patients (SR group). In the other 10 patients (AF group), AF re-occurred (en)
Title	Changes in cytokine concentrations following successful ablation of atrial fibrillation Changes in cytokine concentrations following successful ablation of atrial fibrillation (en)
skos:prefLabel	Changes in cytokine concentrations following successful ablation of atrial fibrillation Changes in cytokine concentrations following successful ablation of atrial fibrillation (en)
skos:notation	RIV/00216208:11120/10:00002766!RIV11-MSM-11120___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM0021620817)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Heřman, Dalibor Štros, Petr Osmančík, Pavel Straka, Z. Budera, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	250288
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/10:00002766
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	atrial fibrillation; ablation; interleukin-6; interleukin-10; CD40L; P-selectin; C-reactive protein (en)
http://linked.open.../riv/klicoveSlovo	C-reactive protein ablation interleukin-6 CD40L atrial fibrillation interleukin-10 P-selectin
http://linked.open...odStatuVydavatele	FR - Francouzská republika
http://linked.open...ontrolniKodProRIV	[F35588C1EF29]
http://linked.open...i/riv/nazevZdroje	European Cytokine Network
http://linked.open...in/vavai/riv/obor	FA
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	21
http://linked.open...iv/tvurceVysledku	Heřman, Dalibor Osmančík, Pavel Peroutka, Zdeněk Štros, Petr Budera, Petr Straka, Zbyněk
http://linked.open...ain/vavai/riv/wos	000285408800008
http://linked.open...n/vavai/riv/zamer	Invasive Approaches to Rescue and Regenerate Jeopardized Myocardium
issn	1148-5493
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	11120

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