About: Potent anti-ischaemic effects of statins in chronic stable angina: incremental benefit beyond lipid lowering?     Goto   Sponge   NotDistinct   Permalink

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  • The DoUble-blind Atorvastatin AmLodipine (DUAAL) trial investigated whether atorvastatin decreases ischaemia by a vascular benefit, independent of low-density lipoprotein cholesterol lowering, in patients with coronary artery disease (CAD), both alone and in combination with the traditional anti-anginal therapy, amlodipine. Methods and results Randomized, double-blind, parallel-group, multicountry trial (2 weeks run-in and 24 weeks active therapy) comparing three treatments: amlodipine, atorvastatin, and amlodipine + atorvastatin; in 311 patients (78% male; mean age 62 years) with stable angina (>/=2 attacks/week), CAD history, >/=3 transient myocardial ischaemia (TMI) episodes, and/or >/=15 min ischaemia on 48 h ambulatory electrocardiographic (AECG) monitoring. Efficacy variables were change in TMI by AECG, exercise ischaemia, angina diary data, and inflammatory biomarkers at Week 26. There was a comparable, highly significant decrease in TMI with amlodipine and atorvastatin, but no additio
  • The DoUble-blind Atorvastatin AmLodipine (DUAAL) trial investigated whether atorvastatin decreases ischaemia by a vascular benefit, independent of low-density lipoprotein cholesterol lowering, in patients with coronary artery disease (CAD), both alone and in combination with the traditional anti-anginal therapy, amlodipine. Methods and results Randomized, double-blind, parallel-group, multicountry trial (2 weeks run-in and 24 weeks active therapy) comparing three treatments: amlodipine, atorvastatin, and amlodipine + atorvastatin; in 311 patients (78% male; mean age 62 years) with stable angina (>/=2 attacks/week), CAD history, >/=3 transient myocardial ischaemia (TMI) episodes, and/or >/=15 min ischaemia on 48 h ambulatory electrocardiographic (AECG) monitoring. Efficacy variables were change in TMI by AECG, exercise ischaemia, angina diary data, and inflammatory biomarkers at Week 26. There was a comparable, highly significant decrease in TMI with amlodipine and atorvastatin, but no additio (en)
Title
  • Potent anti-ischaemic effects of statins in chronic stable angina: incremental benefit beyond lipid lowering?
  • Potent anti-ischaemic effects of statins in chronic stable angina: incremental benefit beyond lipid lowering? (en)
skos:prefLabel
  • Potent anti-ischaemic effects of statins in chronic stable angina: incremental benefit beyond lipid lowering?
  • Potent anti-ischaemic effects of statins in chronic stable angina: incremental benefit beyond lipid lowering? (en)
skos:notation
  • RIV/00216208:11120/10:00002674!RIV11-MSM-11120___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • N
http://linked.open...iv/cisloPeriodika
  • 21
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 280460
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11120/10:00002674
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • amlodipine; atorvastatin; angina; CRP (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [2F14EB4A3D83]
http://linked.open...i/riv/nazevZdroje
  • European Heart Journal
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 31
http://linked.open...iv/tvurceVysledku
  • Bultas, Jan
http://linked.open...ain/vavai/riv/wos
  • 000283926500019
issn
  • 0195-668X
number of pages
http://localhost/t...ganizacniJednotka
  • 11120
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