About: Transient anorexia, hyper-nociception and cognitive impairment in early adjuvant arthritis in rats

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About: Transient anorexia, hyper-nociception and cognitive impairment in early adjuvant arthritis in rats Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Objective. Rheumatoid arthritis (RA) is associated with enhanced pro-inflammatory cytokine levels, pain, anorexia, and cognitive changes. The enhanced production of cytokines appears before the full manifestation of the disease. So far, any experimental data on behavioral effects of early arthritis are lacking. In the present series we describe anorexia early changes in, pain hyper-sensitivity and altered cognitive behavior during the first four days of adjuvant arthritis in rats (AA), when no clinical signs are yet apparent. Methods. AA was induced to male Lewis rats by a single injection of complete Freund's adjuvant (cFA) at the base of the tail. Plasma leptin and ghrelin were measured using specific RIA methods. Gene expressions for food-regulatory peptides, neuropeptide-Y (NPY) and interleukin-1β (IL-1β) in the hypothalamic arcuate nuclei (nARC), were quantitated by TaqMan real-time PCR. Pain sensation was measured on all four limbs and tail by the plantar test. Cognitive functions Objective. Rheumatoid arthritis (RA) is associated with enhanced pro-inflammatory cytokine levels, pain, anorexia, and cognitive changes. The enhanced production of cytokines appears before the full manifestation of the disease. So far, any experimental data on behavioral effects of early arthritis are lacking. In the present series we describe anorexia early changes in, pain hyper-sensitivity and altered cognitive behavior during the first four days of adjuvant arthritis in rats (AA), when no clinical signs are yet apparent. Methods. AA was induced to male Lewis rats by a single injection of complete Freund's adjuvant (cFA) at the base of the tail. Plasma leptin and ghrelin were measured using specific RIA methods. Gene expressions for food-regulatory peptides, neuropeptide-Y (NPY) and interleukin-1β (IL-1β) in the hypothalamic arcuate nuclei (nARC), were quantitated by TaqMan real-time PCR. Pain sensation was measured on all four limbs and tail by the plantar test. Cognitive functions (en)
Title	Transient anorexia, hyper-nociception and cognitive impairment in early adjuvant arthritis in rats Transient anorexia, hyper-nociception and cognitive impairment in early adjuvant arthritis in rats (en)
skos:prefLabel	Transient anorexia, hyper-nociception and cognitive impairment in early adjuvant arthritis in rats Transient anorexia, hyper-nociception and cognitive impairment in early adjuvant arthritis in rats (en)
skos:notation	RIV/00216208:11120/10:00002663!RIV11-MSM-11120___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM0021620816)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Jurčovičová, Jana Štofková, Andrea Škurlová, Martina Deykun, Kateryna
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	293326
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/10:00002663
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Early adjuvant arthritis; Anorexia; Neuropeptide Y; Interleukin 1β; Hypothalamus; Hypernociception (en)
http://linked.open.../riv/klicoveSlovo	Interleukin 1β Anorexia Early adjuvant arthritis Hypernociception Hypothalamus Neuropeptide Y
http://linked.open...odStatuVydavatele	SK - Slovenská republika
http://linked.open...ontrolniKodProRIV	[A280B1C61A84]
http://linked.open...i/riv/nazevZdroje	Endocrine Regulations
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	44
http://linked.open...iv/tvurceVysledku	Jurčovičová, Jana Škurlová, Martina Štofková, Andrea Deykun, Kateryna
http://linked.open...n/vavai/riv/zamer	Název: Patofyziologie neuropsychiatrických onemocnění a její klinické aplikace
issn	1210-0668
number of pages	9 (xsd:int)
http://localhost/t...ganizacniJednotka	11120

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