About: Decreased Apoptosis following Successful Ablation of Atrial Fibrillation

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Objectives: Increased apoptotic processes in tissue samples from hearts in atrial fibrillation (AF) have been previously documented in animals. Whether the restoration of sinus rhythm is associated with decreased apoptosis is not known. The aim of the present study was to establish whether successful epicardial ablation of AF leads to changes in the concentration of serum markers of apoptosis. Methods: Twenty-five patients with AF were prospectively studied. All underwent epicardial isolation of pulmonary veins. The success of the ablation was assessed clinically and with 3 Holter recordings. Blood samples were drawn before surgery, and at 3 and 6 months after. Serum concentrations of Fas (apoptosis-stimulating fragment) and TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) were measured using ELISA. Results: AF was successfully ablated in 15 patients (SR group). In the other 10 patients (AF group), AF recurred during follow-up. Neither group differed with respect to age, sex, left ventr Objectives: Increased apoptotic processes in tissue samples from hearts in atrial fibrillation (AF) have been previously documented in animals. Whether the restoration of sinus rhythm is associated with decreased apoptosis is not known. The aim of the present study was to establish whether successful epicardial ablation of AF leads to changes in the concentration of serum markers of apoptosis. Methods: Twenty-five patients with AF were prospectively studied. All underwent epicardial isolation of pulmonary veins. The success of the ablation was assessed clinically and with 3 Holter recordings. Blood samples were drawn before surgery, and at 3 and 6 months after. Serum concentrations of Fas (apoptosis-stimulating fragment) and TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) were measured using ELISA. Results: AF was successfully ablated in 15 patients (SR group). In the other 10 patients (AF group), AF recurred during follow-up. Neither group differed with respect to age, sex, left ventr (en)
Title	Decreased Apoptosis following Successful Ablation of Atrial Fibrillation Decreased Apoptosis following Successful Ablation of Atrial Fibrillation (en)
skos:prefLabel	Decreased Apoptosis following Successful Ablation of Atrial Fibrillation Decreased Apoptosis following Successful Ablation of Atrial Fibrillation (en)
skos:notation	RIV/00216208:11120/10:00002645!RIV11-MSM-11120___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM0021620817)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Heřman, Dalibor Štros, Petr Vondrák, Karel Osmančík, Pavel Straka, Z. Budera, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	253073
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/10:00002645
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Ablation; Apoptosis; Atrial fibrillation; Fas; TRAIL (en)
http://linked.open.../riv/klicoveSlovo	Ablation Atrial fibrillation Apoptosis TRAIL Fas
http://linked.open...odStatuVydavatele	CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV	[D0F630B1CC92]
http://linked.open...i/riv/nazevZdroje	Cardiology
http://linked.open...in/vavai/riv/obor	FA
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	116
http://linked.open...iv/tvurceVysledku	Heřman, Dalibor Osmančík, Pavel Vondrák, Karel Štros, Petr Budera, Petr Straka, Zbyněk
http://linked.open...ain/vavai/riv/wos	000283036900013
http://linked.open...n/vavai/riv/zamer	Invasive Approaches to Rescue and Regenerate Jeopardized Myocardium
issn	0008-6312
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	11120

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