About: Influence on analgesic activity and serum levels after meloxicam complexation with beta-cyclodextrin in mice and rats

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About: Influence on analgesic activity and serum levels after meloxicam complexation with beta-cyclodextrin in mice and rats Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The aim of the present study was to evaluate and compare the analgesic activity and serum levels of meloxicam (CAS 71125-38-7) after administration of meloxicam associated with beta-cyclodextrin (BCD, CAS 7585-39-9) and unmodified meloxicam. The analgesic activity was measured using the plantar test (rats) and the writhing test (mice). In the plantar test, BCD-meloxicam (3 mg/kg and 10 mg/kg orally) showed higher analgesic activity than corresponding doses of meloxicam alone; in the writhing test BCD-meloxicam (7 mg/kg and 15 mg/kg orally) showed stronger analgesic activity than unmodified meloxicam. Serum levels of meloxicam were significantly higher, at 0.5 h and 1 h after administration of BCD-meloxicam orally than those of unmodified meloxicam (both dosed at 10 mg/kg). The present results suggest that association with beta-cyclodextrin increases the analgesic activity of meloxicam. This may be due to an increased systemic bioavailability of meloxicam after oral administration of its complex with b The aim of the present study was to evaluate and compare the analgesic activity and serum levels of meloxicam (CAS 71125-38-7) after administration of meloxicam associated with beta-cyclodextrin (BCD, CAS 7585-39-9) and unmodified meloxicam. The analgesic activity was measured using the plantar test (rats) and the writhing test (mice). In the plantar test, BCD-meloxicam (3 mg/kg and 10 mg/kg orally) showed higher analgesic activity than corresponding doses of meloxicam alone; in the writhing test BCD-meloxicam (7 mg/kg and 15 mg/kg orally) showed stronger analgesic activity than unmodified meloxicam. Serum levels of meloxicam were significantly higher, at 0.5 h and 1 h after administration of BCD-meloxicam orally than those of unmodified meloxicam (both dosed at 10 mg/kg). The present results suggest that association with beta-cyclodextrin increases the analgesic activity of meloxicam. This may be due to an increased systemic bioavailability of meloxicam after oral administration of its complex with b (en)
Title	Influence on analgesic activity and serum levels after meloxicam complexation with beta-cyclodextrin in mice and rats Influence on analgesic activity and serum levels after meloxicam complexation with beta-cyclodextrin in mice and rats (en)
skos:prefLabel	Influence on analgesic activity and serum levels after meloxicam complexation with beta-cyclodextrin in mice and rats Influence on analgesic activity and serum levels after meloxicam complexation with beta-cyclodextrin in mice and rats (en)
skos:notation	RIV/00216208:11120/10:00002443!RIV11-MZ0-11120___
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(NR9072), S, Z(MSM0021620816)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Procházková, Michaela Slíva, Jiří Janovský, Martin Kršiak, Miloslav Doležal, Tomáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	263889
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/10:00002443
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Beta-cyclodextrin; CAS 7585-39-9; CAS 71125-38-7; Meloxicam, analgesic activity; serum levels (en)
http://linked.open.../riv/klicoveSlovo	Meloxicam Beta-cyclodextrin CAS 71125-38-7 CAS 7585-39-9 serum levels analgesic activity
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[007A3C8DEA20]
http://linked.open...i/riv/nazevZdroje	Arzneimittel-Forschung-Drug Research
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	The role of neurotransmitters in mechanism of action of non-opioid analgesics
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	60
http://linked.open...iv/tvurceVysledku	Janovský, Martin Kršiak, Miloslav Slíva, Jiří Doležal, Tomáš Procházková, Michaela
http://linked.open...ain/vavai/riv/wos	000279453700006
http://linked.open...n/vavai/riv/zamer	Název: Patofyziologie neuropsychiatrických onemocnění a její klinické aplikace
issn	0004-4172
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	11120

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