About: Expression of heat shock protein 70 and NKG2D ligands in acute myeloid leukemia cell lines

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Expression of heat shock protein 70 and NKG2D ligands in acute myeloid leukemia cell lines Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Membrane-bound heat shock protein 70 (HSP70) was found to be tumor-specific and was proposed as a target for immunotherapy. In the present study, we analyzed cell surface and relative gene expression of HSP70 in cell lines established from patients with different acute myeloid leukemia (AML) subtypes, together with the expression of natural killer (NK) cell activation/inhibitory ligands. MATERIALS AND METHODS: Six AML cell lines were included in this study. The relative gene expression of HSP70 was analyzed using the real-time reverse-transcriptase polymerase chain reaction. Surface expression of HSP70 and NK cell ligands was analyzed using flow cytometry. RESULTS: All cell lines overexpressed HSP70; however, its mRNA levels were not elevated. The expression of NKG2D activation ligands was heterogeneous. CONCLUSION: Our study is the first to describe long-term stationary cell surface expression of HSP70 in different subtypes of AML. Combined with the results of the gene expression experiments these da Membrane-bound heat shock protein 70 (HSP70) was found to be tumor-specific and was proposed as a target for immunotherapy. In the present study, we analyzed cell surface and relative gene expression of HSP70 in cell lines established from patients with different acute myeloid leukemia (AML) subtypes, together with the expression of natural killer (NK) cell activation/inhibitory ligands. MATERIALS AND METHODS: Six AML cell lines were included in this study. The relative gene expression of HSP70 was analyzed using the real-time reverse-transcriptase polymerase chain reaction. Surface expression of HSP70 and NK cell ligands was analyzed using flow cytometry. RESULTS: All cell lines overexpressed HSP70; however, its mRNA levels were not elevated. The expression of NKG2D activation ligands was heterogeneous. CONCLUSION: Our study is the first to describe long-term stationary cell surface expression of HSP70 in different subtypes of AML. Combined with the results of the gene expression experiments these da (en)
Title	Expression of heat shock protein 70 and NKG2D ligands in acute myeloid leukemia cell lines Expression of heat shock protein 70 and NKG2D ligands in acute myeloid leukemia cell lines (en)
skos:prefLabel	Expression of heat shock protein 70 and NKG2D ligands in acute myeloid leukemia cell lines Expression of heat shock protein 70 and NKG2D ligands in acute myeloid leukemia cell lines (en)
skos:notation	RIV/00216208:11120/10:00002388!RIV11-MSM-11120___
http://linked.open...avai/riv/aktivita	R
http://linked.open...avai/riv/aktivity	R
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Sedláčková, Lucie Volchenkov, Roman Kozák, Tomáš Špaček, M. Hromadníková, Ilona
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	258520
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/10:00002388
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	HSP70; acute myeloid leukemia; gene expression; cell surface expression; NK cell ligands; RT-PCR (en)
http://linked.open.../riv/klicoveSlovo	gene expression acute myeloid leukemia RT-PCR HSP70 NK cell ligands cell surface expression
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[EFF474A824DE]
http://linked.open...i/riv/nazevZdroje	Journal of Receptors and Signal Transduction
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	30
http://linked.open...iv/tvurceVysledku	Kozák, Tomáš Špaček, Martin Sedláčková, Lucie Hromadníková, Ilona Volchenkov, Roman
http://linked.open...ain/vavai/riv/wos	000277004700004
issn	1079-9893
number of pages	9 (xsd:int)
http://localhost/t...ganizacniJednotka	11120

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 48 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software