About: TCF7L2 rs7903146-macronutrient interaction in obese individuals' responses to a 10-wk randomized hypoenergetic diet

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About: TCF7L2 rs7903146-macronutrient interaction in obese individuals' responses to a 10-wk randomized hypoenergetic diet Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Transcription factor 7-like 2 (TCF7L2) rs7903146 associates with type 2 diabetes and may operate via impaired glucagon-like peptide 1 secretion, which is stimulated more by fat than by carbohydrate ingestion. The objective was to examine the interaction between TCF7L2 rs7903146 and dietary fat and carbohydrate [high-fat, low-carbohydrate: 40-45% of energy as fat (HF); compared with low-fat, high-carbohydrate: 20-25% of energy as fat (LF)] in obese individuals' responses to a 10-wk hypoenergetic diet (-600 kcal/d). Our results suggest that obese individuals who are homozygous for the TCF7L2 rs7903146 T risk allele are more sensitive to LF than to HF weight-loss diets. Am J Clin Nutr 2010;91:472-9. Transcription factor 7-like 2 (TCF7L2) rs7903146 associates with type 2 diabetes and may operate via impaired glucagon-like peptide 1 secretion, which is stimulated more by fat than by carbohydrate ingestion. The objective was to examine the interaction between TCF7L2 rs7903146 and dietary fat and carbohydrate [high-fat, low-carbohydrate: 40-45% of energy as fat (HF); compared with low-fat, high-carbohydrate: 20-25% of energy as fat (LF)] in obese individuals' responses to a 10-wk hypoenergetic diet (-600 kcal/d). Our results suggest that obese individuals who are homozygous for the TCF7L2 rs7903146 T risk allele are more sensitive to LF than to HF weight-loss diets. Am J Clin Nutr 2010;91:472-9. (en)
Title	TCF7L2 rs7903146-macronutrient interaction in obese individuals' responses to a 10-wk randomized hypoenergetic diet TCF7L2 rs7903146-macronutrient interaction in obese individuals' responses to a 10-wk randomized hypoenergetic diet (en)
skos:prefLabel	TCF7L2 rs7903146-macronutrient interaction in obese individuals' responses to a 10-wk randomized hypoenergetic diet TCF7L2 rs7903146-macronutrient interaction in obese individuals' responses to a 10-wk randomized hypoenergetic diet (en)
skos:notation	RIV/00216208:11120/10:00002033!RIV10-MSM-11120___
http://linked.open...avai/riv/aktivita	R
http://linked.open...avai/riv/aktivity	R
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Klimčáková, Eva
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	291870
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/10:00002033
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Homeostasis model assessment; type-2 diabetic patients; beta-cell function; insulin; resistant (en)
http://linked.open.../riv/klicoveSlovo	Homeostasis model assessment beta-cell function type-2 diabetic patients resistant insulin
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[44F2F7A17F8A]
http://linked.open...i/riv/nazevZdroje	American Journal of Clinical Nutrition
http://linked.open...in/vavai/riv/obor	FB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	16 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	91
http://linked.open...iv/tvurceVysledku	Klimčáková, Eva Froguel, P. Pedersen, O. Astrup, A. Blaak, E. E. Grau, K. Langin, D. Oppert, J. M. Arner, P. Cauchi, S. Holst, C. Macdonald, A. Martinez, J. A Rossner, S. Saris, W.H.M. Sorensen, TIA
http://linked.open...ain/vavai/riv/wos	000273947500024
issn	0002-9165
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	11120

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