About: The role of SRc-3 in human breast cancer

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About: The role of SRc-3 in human breast cancer Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Members of the nuclear receptor superfamily are ligand-regulated transcription factors involved in the control of a broad range of normal physiological and disease processes. The estrogen receptor alpha (ER alpha) is a member of the steriod receptor family, which is part of the nuclear receptor superfamily. ER alpha it is important for many biological processes and plays a key role in the pathogenesis of breast cancer. Gene regulation by ER alpha requires the recruitment of a multitude of transcriptional co-regulators to the promoters of estrogen-responsive genes. There is evidence in support of the involvement of these co-regulators in breast cancer progression. We review the role of steroid receptor co-activator-3 (SRC-3), which is frequently amplified in breast cancer, and its role in breast cancer risk, outcome and response to endocrine therapy in patients with breast cancer. Members of the nuclear receptor superfamily are ligand-regulated transcription factors involved in the control of a broad range of normal physiological and disease processes. The estrogen receptor alpha (ER alpha) is a member of the steriod receptor family, which is part of the nuclear receptor superfamily. ER alpha it is important for many biological processes and plays a key role in the pathogenesis of breast cancer. Gene regulation by ER alpha requires the recruitment of a multitude of transcriptional co-regulators to the promoters of estrogen-responsive genes. There is evidence in support of the involvement of these co-regulators in breast cancer progression. We review the role of steroid receptor co-activator-3 (SRC-3), which is frequently amplified in breast cancer, and its role in breast cancer risk, outcome and response to endocrine therapy in patients with breast cancer. (en)
Title	The role of SRc-3 in human breast cancer The role of SRc-3 in human breast cancer (en)
skos:prefLabel	The role of SRc-3 in human breast cancer The role of SRc-3 in human breast cancer (en)
skos:notation	RIV/00216208:11120/10:00001996!RIV10-MSM-11120___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM0021620808)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Gojiš, Ondřej
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	285751
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/10:00001996
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	breast cancer; Steroid-receptor coactivator (en)
http://linked.open.../riv/klicoveSlovo	breast cancer Steroid-receptor coactivator
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[6F0892959FF1]
http://linked.open...i/riv/nazevZdroje	Nature Reviews Clinical Oncology
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	7
http://linked.open...iv/tvurceVysledku	Gojiš, Ondřej Palmieri, C. Cleator, S. Coombes, C. R. Gudi, M. Hogben, K. Rudraraju, B. Sousha, S.
http://linked.open...ain/vavai/riv/wos	000274082600009
http://linked.open...n/vavai/riv/zamer	Molekulárně biologické, genetické a epigenetické aspekty vzniku a rozvoje modelových tumorů dospělého věku. Význam pro epidemiologii, časnou diagnostiku a léčbu
issn	1759-4774
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	11120

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