About: Carbon Nanotubes Activate Blood Platelets by Inducing Extracellular Ca(2+) Influx Sensitive to Calcium Entry Inhibitors

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About: Carbon Nanotubes Activate Blood Platelets by Inducing Extracellular Ca(2+) Influx Sensitive to Calcium Entry Inhibitors Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1021/nl901603k
Description	To elucidate a mechanism of prothrombotic effects of carbon nanotubes (CNTs), we report here that multiwalled CNTs activate blood platelets by inducing extracellular Ca(2+) influx that could be inhibited by calcium channel blockers; SKF 96365 and 2-APB. We also demonstrate platelet aggregating activity of different single-walled and multiwalled CNTs. In addition, we show that CNT-induced platelet activation is associated with a marked release of platelet membrane microparticles positive for the granular secretion markers CD62P and CD63. To elucidate a mechanism of prothrombotic effects of carbon nanotubes (CNTs), we report here that multiwalled CNTs activate blood platelets by inducing extracellular Ca(2+) influx that could be inhibited by calcium channel blockers; SKF 96365 and 2-APB. We also demonstrate platelet aggregating activity of different single-walled and multiwalled CNTs. In addition, we show that CNT-induced platelet activation is associated with a marked release of platelet membrane microparticles positive for the granular secretion markers CD62P and CD63. (en)
Title	Carbon Nanotubes Activate Blood Platelets by Inducing Extracellular Ca(2+) Influx Sensitive to Calcium Entry Inhibitors Carbon Nanotubes Activate Blood Platelets by Inducing Extracellular Ca(2+) Influx Sensitive to Calcium Entry Inhibitors (en)
skos:prefLabel	Carbon Nanotubes Activate Blood Platelets by Inducing Extracellular Ca(2+) Influx Sensitive to Calcium Entry Inhibitors Carbon Nanotubes Activate Blood Platelets by Inducing Extracellular Ca(2+) Influx Sensitive to Calcium Entry Inhibitors (en)
skos:notation	RIV/00216208:11120/09:00003815!RIV12-MSM-11120___
http://linked.open...avai/riv/aktivita	I S Z
http://linked.open...avai/riv/aktivity	I, S, Z(MSM0021620806)
http://linked.open...iv/cisloPeriodika	9
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Šemberová, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	305865
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/09:00003815
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Cell-Membrane Microparticles; Toxicity; Nanoparticles; Nanomaterials; Aggregation; Mechanism; Penetration; Particles; Channels; Release (en)
http://linked.open.../riv/klicoveSlovo	Nanoparticles Particles Release Mechanism Penetration Cell-Membrane Microparticles Nanomaterials Channels Aggregation Toxicity
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[A29A5FBFED13]
http://linked.open...i/riv/nazevZdroje	Nano Letters
http://linked.open...in/vavai/riv/obor	CF
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	9
http://linked.open...iv/tvurceVysledku	Šemberová, Jana Simak, Jan
http://linked.open...ain/vavai/riv/wos	000269654900039
http://linked.open...n/vavai/riv/zamer	Molekulární biologie a patologie buňky za normy a u vybraných klinicky závažných patologických procesů
issn	1530-6984
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1021/nl901603k
http://localhost/t...ganizacniJednotka	11120

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