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  • Interactions between the neuroendocrine and immune system play an important role in maintaining and restoring homeostasis. Any dysfunction may result in susceptible individuals in septicemia and bacterial infection. We studied toll-like receptors (TLR) and prolactin (PRL) role in defensive reaction of immune system to bacterial infection and hypothesized that PRL takes part in this defensive reaction and has contraregulative role against activation of adrenocortical system. Measuring the expression of PRL, TLR 2 and 4 mRNA levels in CD14+ cells derived from peripheral blood of 20 septic patients at the time of admission (sample A) and then at the moment when symptoms of sepsis disappeared (sample B) revealed no change between the two samples. Similarly, we were not able to detect any statistically significant difference in PRL, TLR2 and 4 protein levels measured by FCM. Preliminary results do not confirm that septic statuses change peripheral PRL, TLR2 and TLR4 expression in CD14+ cells.
  • Interactions between the neuroendocrine and immune system play an important role in maintaining and restoring homeostasis. Any dysfunction may result in susceptible individuals in septicemia and bacterial infection. We studied toll-like receptors (TLR) and prolactin (PRL) role in defensive reaction of immune system to bacterial infection and hypothesized that PRL takes part in this defensive reaction and has contraregulative role against activation of adrenocortical system. Measuring the expression of PRL, TLR 2 and 4 mRNA levels in CD14+ cells derived from peripheral blood of 20 septic patients at the time of admission (sample A) and then at the moment when symptoms of sepsis disappeared (sample B) revealed no change between the two samples. Similarly, we were not able to detect any statistically significant difference in PRL, TLR2 and 4 protein levels measured by FCM. Preliminary results do not confirm that septic statuses change peripheral PRL, TLR2 and TLR4 expression in CD14+ cells. (en)
Title
  • The role of prolactin in immune response to bacterial infection (en)
  • The role of prolactin in immune response to bacterial infection
skos:prefLabel
  • The role of prolactin in immune response to bacterial infection (en)
  • The role of prolactin in immune response to bacterial infection
skos:notation
  • RIV/00216208:11120/09:00002109!RIV13-MZ0-11120___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(NS9970)
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
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http://linked.open...dnocenehoVysledku
  • 339751
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11120/09:00002109
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • innate immunity; TLR; PRL; Sepsis (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [D3CE8B2E899A]
http://linked.open...v/mistoKonaniAkce
  • Berlin
http://linked.open...i/riv/mistoVydani
  • Bologna
http://linked.open...i/riv/nazevZdroje
  • Proceeding of the 2nd European Congress of Immunology
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http://linked.open...ichTvurcuVysledku
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http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Černá, Marie
  • Čejková, Pavlína
  • Janatová, Kateřina
http://linked.open...vavai/riv/typAkce
http://linked.open...ain/vavai/riv/wos
  • 000292190700006
http://linked.open.../riv/zahajeniAkce
number of pages
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  • Medimond
https://schema.org/isbn
  • 978-88-7587-523-7
http://localhost/t...ganizacniJednotka
  • 11120
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