About: CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance

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About: CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We show here high levels of expression and secretion of the chemokine CXC ligand 5 (CXCL5) in the macrophage fraction of white adipose tissue (WAT). Moreover, we find that CXCL5 is dramatically increased in serum of human obese compared to lean subjects. Conversely, CXCL5 concentration is decreased in obese subjects after a weight reduction program, or in obese non-insulin-resistant, compared to insulin-resistant, subjects. Most importantly we demonstrate that treatment with recombinant CXCL5 blocks insulin-stimulated glucose uptake in muscle in mice. CXCL5 blocks insulin signaling by activating the Jak2/STAT5/SOCS2 pathway. Finally, by treating obese, insulin-resistant mice with either anti-CXCL5 neutralizing antibodies or antagonists of CXCR2, which is the CXCL5 receptor, we demonstrate that CXCL5 mediates insulin resistance. Furthermore CXCR2-/- mice are protected against obesity-induced insulin resistance. Taken together, these results show that secretion of CXCL5 by WAT resident macrophages repre We show here high levels of expression and secretion of the chemokine CXC ligand 5 (CXCL5) in the macrophage fraction of white adipose tissue (WAT). Moreover, we find that CXCL5 is dramatically increased in serum of human obese compared to lean subjects. Conversely, CXCL5 concentration is decreased in obese subjects after a weight reduction program, or in obese non-insulin-resistant, compared to insulin-resistant, subjects. Most importantly we demonstrate that treatment with recombinant CXCL5 blocks insulin-stimulated glucose uptake in muscle in mice. CXCL5 blocks insulin signaling by activating the Jak2/STAT5/SOCS2 pathway. Finally, by treating obese, insulin-resistant mice with either anti-CXCL5 neutralizing antibodies or antagonists of CXCR2, which is the CXCL5 receptor, we demonstrate that CXCL5 mediates insulin resistance. Furthermore CXCR2-/- mice are protected against obesity-induced insulin resistance. Taken together, these results show that secretion of CXCL5 by WAT resident macrophages repre (en)
Title	CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance (en)
skos:prefLabel	CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance (en)
skos:notation	RIV/00216208:11120/09:00001512!RIV10-MSM-11120___
http://linked.open...avai/riv/aktivita	R
http://linked.open...avai/riv/aktivity	R
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Štich, Vladimír Šiklová-Vítková, Michaela
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	308757
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/09:00001512
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	activated-receptor-gamma; peptide ena-78; chemoattractant protein-1; promotes adipogenesis; energy-balance; inflammation; expression; accumulation; macrophages; adipocytes (en)
http://linked.open.../riv/klicoveSlovo	activated-receptor-gamma energy-balance peptide ena-78 promotes adipogenesis accumulation expression inflammation macrophages adipocytes chemoattractant protein-1
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[9EA15EC6A90B]
http://linked.open...i/riv/nazevZdroje	Cell Metabolism
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	23 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	9
http://linked.open...iv/tvurceVysledku	Yamamoto, H. Štich, Vladimír Vítková, Michaela Langin, D. Schmidt, J. Annicotte, J. S. Chavey, C. Clape, C. Fajas, L. Guma, A. Hotamisligil, G. S. Iankova, I. Jardin-Watelet, B. Lagarrigue, S. Lazennec, G. Mataki, C. Renard, E. Sanches, R. Strieter, R. Teyssier, J. Tuthill, A. Vidal-Puig, A. Zorzano, A.
http://linked.open...ain/vavai/riv/wos	000265028600007
issn	1550-4131
number of pages	11 (xsd:int)
http://localhost/t...ganizacniJednotka	11120

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