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| rdf:type
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| Description
| - To identify specific treatment-emergent symptoms in response to antidepressant therapy in depression preceding bipolar disorder. Methods: Retrospective chart review of response to antidepressants in %22pre-bipolar%22 depression, compared to a matched unipolar sample. Results: Family history of completed suicide (p=0.0003) and bipolar disorder (p=0.004) were more common in the pre-bipolar subgroup. Earlier age of onset of diagnosed depression (p=0.005) as well as even earlier episodes of untreated retrospectively diagnosed major depression (p<0.0001) were associated with a future bipolar course. The pre-bipolar group was less likely to respond to antidepressant treatment (p=0.009). Treatment-emergent %22mixed%22 symptoms (two or more symptoms of DSM IV mania, mood lability, irritability/rage with co-existing depression) and in particular, %22serious symptoms%22 (treatment emergent or increased agitation, rage or suicidality) occurred more commonly in the bipolar group. The two variables that best accounted for the between-group differences in logistic regression, were early age at first symptoms of depression and treatment-emergent agitation. Conclusions: Family history of completed suicide and/or bipolar disorder, early onset of depressive symptoms as well as treatment-emergent %22mixed%22 symptoms are common in depression preceding the diagnosis of bipolar disorder.
- To identify specific treatment-emergent symptoms in response to antidepressant therapy in depression preceding bipolar disorder. Methods: Retrospective chart review of response to antidepressants in %22pre-bipolar%22 depression, compared to a matched unipolar sample. Results: Family history of completed suicide (p=0.0003) and bipolar disorder (p=0.004) were more common in the pre-bipolar subgroup. Earlier age of onset of diagnosed depression (p=0.005) as well as even earlier episodes of untreated retrospectively diagnosed major depression (p<0.0001) were associated with a future bipolar course. The pre-bipolar group was less likely to respond to antidepressant treatment (p=0.009). Treatment-emergent %22mixed%22 symptoms (two or more symptoms of DSM IV mania, mood lability, irritability/rage with co-existing depression) and in particular, %22serious symptoms%22 (treatment emergent or increased agitation, rage or suicidality) occurred more commonly in the bipolar group. The two variables that best accounted for the between-group differences in logistic regression, were early age at first symptoms of depression and treatment-emergent agitation. Conclusions: Family history of completed suicide and/or bipolar disorder, early onset of depressive symptoms as well as treatment-emergent %22mixed%22 symptoms are common in depression preceding the diagnosis of bipolar disorder. (en)
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| Title
| - Antidepressant monotherapy in pre-bipolar depression; predictive value and inherent risk
- Antidepressant monotherapy in pre-bipolar depression; predictive value and inherent risk (en)
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| skos:prefLabel
| - Antidepressant monotherapy in pre-bipolar depression; predictive value and inherent risk
- Antidepressant monotherapy in pre-bipolar depression; predictive value and inherent risk (en)
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| skos:notation
| - RIV/00216208:11120/08:43906871!RIV13-MSM-11120___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11120/08:43906871
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - antidepressant medication; mixed symptoms; depressive mixed state; unipolar depression; bipolar depression (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Journal of Affective Disorders
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Alda, Martin
- Hájek, Tomáš
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| http://linked.open...ain/vavai/riv/wos
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| issn
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| number of pages
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| http://bibframe.org/vocab/doi
| - 10.1016/j.jad.2007.08.003
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| http://localhost/t...ganizacniJednotka
| |
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