About: Pituitary volumes in relatives of bipolar patients

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	ncreased, decreased, as well as unchanged pituitary volumes have been reported in bipolar disorders (BD). It is unclear, whether abnormal pituitary volumes increase vulnerability for BD (primary vulnerability marker), or are secondary to burden of illness. To address this question, we performed the first high-risk study of pituitary volumes in affected and unaffected relatives of bipolar subjects. Method High-risk participants (age range 15-30 years) were recruited from families multiply affected with BD and included 24 unaffected, 19 affected subjects with first or second degree bipolar I or II relative, matched by age and sex with 31 controls without a personal or family history of psychiatric disorders. Pituitary volumes were measured on 1.5 T 3D anatomical MRI images using standard methods. Results We found comparable pituitary volumes among unaffected, affected relatives of bipolar patients and controls. There were no differences in pituitary volumes between male and female subjects nor was there ncreased, decreased, as well as unchanged pituitary volumes have been reported in bipolar disorders (BD). It is unclear, whether abnormal pituitary volumes increase vulnerability for BD (primary vulnerability marker), or are secondary to burden of illness. To address this question, we performed the first high-risk study of pituitary volumes in affected and unaffected relatives of bipolar subjects. Method High-risk participants (age range 15-30 years) were recruited from families multiply affected with BD and included 24 unaffected, 19 affected subjects with first or second degree bipolar I or II relative, matched by age and sex with 31 controls without a personal or family history of psychiatric disorders. Pituitary volumes were measured on 1.5 T 3D anatomical MRI images using standard methods. Results We found comparable pituitary volumes among unaffected, affected relatives of bipolar patients and controls. There were no differences in pituitary volumes between male and female subjects nor was there (en)
Title	Pituitary volumes in relatives of bipolar patients - High-risk study Pituitary volumes in relatives of bipolar patients - High-risk study (en)
skos:prefLabel	Pituitary volumes in relatives of bipolar patients - High-risk study Pituitary volumes in relatives of bipolar patients - High-risk study (en)
skos:notation	RIV/00216208:11120/08:00002193!RIV11-MSM-11120___
http://linked.open...avai/riv/aktivita	N V
http://linked.open...avai/riv/aktivity	N, V
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Hájek, Tomáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	386705
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/08:00002193
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	bipolar disorders; MRI; pituitary; offspring; high-risk (en)
http://linked.open.../riv/klicoveSlovo	offspring high-risk MRI pituitary bipolar disorders
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[9574E294A5A8]
http://linked.open...i/riv/nazevZdroje	European Archives of Psychiatry and Clinical Neuroscience
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	258
http://linked.open...iv/tvurceVysledku	Hájek, Tomáš Gunde, Eva Bernier, D.
http://linked.open...ain/vavai/riv/wos	000258654900006
issn	0940-1334
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	11120

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