About: DNA repair genetic polymorphisms and risk of colorectal cancer in the Czech Republic

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About: DNA repair genetic polymorphisms and risk of colorectal cancer in the Czech Republic Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Colorectal cancer represents a complex disease where susceptibility may be influenced by genetic polymorphisms in the DNA repair system. In the present study we investigated the role of nine single nucleotide polymorphisms in eight DNA repair genes on the risk of colorectal cancer in a hospital-based case-control population (532 cases and 532 sex- and age-matched controls). Data analysis showed that the variant allele homozygotes for the Asn148Glu polymorphism in the APE1 gene were at a statistically non-significant increased risk of colorectal cancer Colorectal cancer represents a complex disease where susceptibility may be influenced by genetic polymorphisms in the DNA repair system. In the present study we investigated the role of nine single nucleotide polymorphisms in eight DNA repair genes on the risk of colorectal cancer in a hospital-based case-control population (532 cases and 532 sex- and age-matched controls). Data analysis showed that the variant allele homozygotes for the Asn148Glu polymorphism in the APE1 gene were at a statistically non-significant increased risk of colorectal cancer (en)
Title	DNA repair genetic polymorphisms and risk of colorectal cancer in the Czech Republic DNA repair genetic polymorphisms and risk of colorectal cancer in the Czech Republic (en)
skos:prefLabel	DNA repair genetic polymorphisms and risk of colorectal cancer in the Czech Republic DNA repair genetic polymorphisms and risk of colorectal cancer in the Czech Republic (en)
skos:notation	RIV/00216208:11120/08:00001636!RIV10-MZ0-11120___
http://linked.open...avai/riv/aktivita	P R S Z
http://linked.open...avai/riv/aktivity	P(GA310/05/2626), P(NR8563), R, S, Z(AV0Z50390512), Z(MSM0021620808)
http://linked.open...iv/cisloPeriodika	1-2
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Vodička, Pavel Poláková, Veronika
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	364046
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/08:00001636
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	colorectal cancer; individual susceptibility; DNA repair; single-nucleotide polymorphisms; case-control study (en)
http://linked.open.../riv/klicoveSlovo	single-nucleotide polymorphisms colorectal cancer individual susceptibility DNA repair case-control study
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[23501D37F53D]
http://linked.open...i/riv/nazevZdroje	Mutation Research
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	14 (xsd:int)
http://linked.open...vavai/riv/projekt	Case-control study on colorectal carcinoma: genetic profiling of xenobiotic metabolising and DNA repair enzymes Genetic profile of biotransformation and DNA repair genes in cancer patients from the Czech Republic.
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	638
http://linked.open...iv/tvurceVysledku	Barale, R. Hemminki, K. Novotný, J. Vodička, Pavel Vodičková, Ludmila Šmerhovský, Zdeněk Poláková, Veronika Kumar, R. Naccarati, A. Pardini, B. Bortlík, M. Tulupová, E. Hánová, M. Slyšková, J.
http://linked.open...ain/vavai/riv/wos	000253034000018
http://linked.open...n/vavai/riv/zamer	Molekulární, buněčné a systémové mechanizmy závažných onemocnění lidského organizmu, jejich diagnostika, terapie a farmakoterapie Molekulárně biologické, genetické a epigenetické aspekty vzniku a rozvoje modelových tumorů dospělého věku. Význam pro epidemiologii, časnou diagnostiku a léčbu
issn	0027-5107
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	11120

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