About: Chromosomal damage and polymorphisms of DNA repair genes XRCC1 and XRCC3 in workers exposed to chromium     Goto   Sponge   NotDistinct   Permalink

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  • Our study investigates chromosomal damage related to chromium exposure, considering the role of polymorphisms in relevant DNA repair genes. 39 male welders exposed to chromium for 10.2+/-1.67 years and 31 male controls were assayed for structural chromosomal aberrations (conventional cytogenetic analysis). Chromosomal type breaks were almost two-fold higher in exposed than in control individuals. The highest frequency of total chromosomal aberrations was recorded in individuals with homozygous variant Gln/Gln cariers (2.14%) in XRCC1* Arg-399Gln and the lowest in those with the wild-type Arg/Arg cariers (1.33%).
  • Our study investigates chromosomal damage related to chromium exposure, considering the role of polymorphisms in relevant DNA repair genes. 39 male welders exposed to chromium for 10.2+/-1.67 years and 31 male controls were assayed for structural chromosomal aberrations (conventional cytogenetic analysis). Chromosomal type breaks were almost two-fold higher in exposed than in control individuals. The highest frequency of total chromosomal aberrations was recorded in individuals with homozygous variant Gln/Gln cariers (2.14%) in XRCC1* Arg-399Gln and the lowest in those with the wild-type Arg/Arg cariers (1.33%). (en)
Title
  • Chromosomal damage and polymorphisms of DNA repair genes XRCC1 and XRCC3 in workers exposed to chromium
  • Chromosomal damage and polymorphisms of DNA repair genes XRCC1 and XRCC3 in workers exposed to chromium (en)
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  • Chromosomal damage and polymorphisms of DNA repair genes XRCC1 and XRCC3 in workers exposed to chromium
  • Chromosomal damage and polymorphisms of DNA repair genes XRCC1 and XRCC3 in workers exposed to chromium (en)
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  • RIV/00216208:11120/08:00001635!RIV11-MSM-11120___
http://linked.open...avai/riv/aktivita
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  • S, Z(AV0Z50390703)
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  • 5
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  • 359891
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  • RIV/00216208:11120/08:00001635
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  • chromosomal aberrations; polymorphisms; repair genes; XRCC1; XRCC3; chromium exposure (en)
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  • SE - Švédské království
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  • [9A7E583112C5]
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  • Neuroendocrinology Letters
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  • 29
http://linked.open...iv/tvurceVysledku
  • Vodička, Pavel
  • Poláková, Veronika
http://linked.open...ain/vavai/riv/wos
  • 000261553200012
http://linked.open...n/vavai/riv/zamer
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  • 0172-780X
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  • 11120
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