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  • Atopy is a predisposition to hyperproduction of immunoglobulin E (IgE) against common environmental allergens.. The development of these diseases is influenced by both genetic and environmental factors. As the first step in study of such gene-environment interactions we analyzed the specificity and intensity of sensitization to 40 different allergens in atopic patients from the Czech Republic and Ukradne. We found highly significant differences in sensitization to airborne allergens between patients from the two countries. The most pronounced allergens from Ukradne were dust mites allergens and cat. In the atopic patients from the Czech Republic the level of sensitization to these allergens was similar, but the level of sensitization to outdoor allergens, grasses and trees was dramatically higher. The higher sensitization levels to outdoor allergens in the Czech Republic suggest an influence of westernization on development of allergic reactivity.
  • Atopy is a predisposition to hyperproduction of immunoglobulin E (IgE) against common environmental allergens.. The development of these diseases is influenced by both genetic and environmental factors. As the first step in study of such gene-environment interactions we analyzed the specificity and intensity of sensitization to 40 different allergens in atopic patients from the Czech Republic and Ukradne. We found highly significant differences in sensitization to airborne allergens between patients from the two countries. The most pronounced allergens from Ukradne were dust mites allergens and cat. In the atopic patients from the Czech Republic the level of sensitization to these allergens was similar, but the level of sensitization to outdoor allergens, grasses and trees was dramatically higher. The higher sensitization levels to outdoor allergens in the Czech Republic suggest an influence of westernization on development of allergic reactivity. (en)
  • Atopie je predispozice k hyperprodukci IgE proti okolním alergenům. Vývoj nemoci je ovlivněn vlivy genetickými a prostředím. Analyzovali jsme specifitu a intenzitu senzibilizace proti alergenům u atopických pacientů v České republice a na Ukrajině. Byly nalezeny významné rozdíly, nejvýznamnější alergeny na Ukrajině byly z roztočů a z koček, v ČR byla vyšší senzibilizace proti pylovým alergenům. Tento nález může odrážet vliv západního životního stylu na populaci. (cs)
Title
  • Different Environmental Influences on Aetiology of Atopic Diseases in European Populations as a Basis for Study of Gene-Environment Interactions
  • Different Environmental Influences on Aetiology of Atopic Diseases in European Populations as a Basis for Study of Gene-Environment Interactions (en)
  • Odlišné vlivy prostředí na etiologii atopických chorob v evropských populacích jako základ studia interakce genů a okolního prostředí (cs)
skos:prefLabel
  • Different Environmental Influences on Aetiology of Atopic Diseases in European Populations as a Basis for Study of Gene-Environment Interactions
  • Different Environmental Influences on Aetiology of Atopic Diseases in European Populations as a Basis for Study of Gene-Environment Interactions (en)
  • Odlišné vlivy prostředí na etiologii atopických chorob v evropských populacích jako základ studia interakce genů a okolního prostředí (cs)
skos:notation
  • RIV/00216208:11120/08:00000994!RIV09-MSM-11120___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM0021620812)
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 363548
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11120/08:00000994
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Atopy; sensitization; IgE; mites and pollen allergens (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [A291758126E3]
http://linked.open...i/riv/mistoVydani
  • New York
http://linked.open...i/riv/nazevZdroje
  • Genetic Predisposition to Disease
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...v/pocetStranKnihy
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Král, V.
  • Kučera, Petr
  • Lipoldová, Marie
  • Gusareva, E. S.
  • Havelková, H.
  • Belozorova, A. P.
  • Blažková, H.
  • Savvo, A.
http://linked.open...n/vavai/riv/zamer
number of pages
http://purl.org/ne...btex#hasPublisher
  • Nova Science Publishers
https://schema.org/isbn
  • 978-1-60456-835-6
http://localhost/t...ganizacniJednotka
  • 11120
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