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| Description
| - We tested the effects of various types of fatty acids, differing in the degree of saturation and in the cis/trans configuration of the double bond, on the growth and viability of NES2Y cells (a human pancreatic beta-cell line). We found that saturated fatty acids, i.e. palmitic and stearic acids, at a physiologically relevant concentration of 1 mM and higher concentrations, induced death of the beta-cells in contrast to their unsaturated counterparts, i.e. palmitoleic and oleic acids. Unsaturated elaidic acid with a trans double bond exerted significant inhibition of growth of the beta-cells at a concentration approximately ten times lower, i.e. 0.1 mM vs. 1 mM, than counterpart oleic acid with a cis double bond. Beta-cell death induced by saturated fatty acids in NES2Y cells was related to significant increase of caspase-2 activity but not to caspase-3 activation.
- We tested the effects of various types of fatty acids, differing in the degree of saturation and in the cis/trans configuration of the double bond, on the growth and viability of NES2Y cells (a human pancreatic beta-cell line). We found that saturated fatty acids, i.e. palmitic and stearic acids, at a physiologically relevant concentration of 1 mM and higher concentrations, induced death of the beta-cells in contrast to their unsaturated counterparts, i.e. palmitoleic and oleic acids. Unsaturated elaidic acid with a trans double bond exerted significant inhibition of growth of the beta-cells at a concentration approximately ten times lower, i.e. 0.1 mM vs. 1 mM, than counterpart oleic acid with a cis double bond. Beta-cell death induced by saturated fatty acids in NES2Y cells was related to significant increase of caspase-2 activity but not to caspase-3 activation. (en)
- Testovali jsme vliv několika mastných kyselin lišících se stupněm saturace a cis/trans konfigurací dvojné vazbyna růst a viabilitu buněk NES2Y (linie lidských pankreatických beta buněk). Zjistili jsme, ze saturované mastné kyseliny, tj. palmitová a stearová kyselina, indukují ve fyziologicky relevantní koncentraci 1 mM a vyšší apoptózu beta buněk narozdíl od svých nenasycených protějšků, tj. kyseliny palmitolejové a olejové. Kyselina elaidová, nesaturovaná mastná kyselina s trans dvojnou vazbou, měla signifikantní efekt na růst buněk už v koncentraci 10x nižší (tj. 0,1 mM vs. 1 mM) než její protějšek s cis dvojnou vazbou kyselina olejová. Buněčná smrt indukovaná u buněk NES2Y působením nasycených mastných kyselin byla spojena se signifikantní aktivací kaspázy-2, ale ne s aktivací kaspázy-3. (cs)
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| Title
| - Comparison of the effect of individual saturated and unsaturated fatty acids on cell growth and death induction in the human pancreatic beta-cell line NES2Y
- Porovnání vlivu jednotlivých nasycených a nenasycených mastných kyselin na růst a indukci buněčné smrti u linie lidských pankreatických β buněk linie NES2Y (cs)
- Comparison of the effect of individual saturated and unsaturated fatty acids on cell growth and death induction in the human pancreatic beta-cell line NES2Y (en)
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| skos:prefLabel
| - Comparison of the effect of individual saturated and unsaturated fatty acids on cell growth and death induction in the human pancreatic beta-cell line NES2Y
- Porovnání vlivu jednotlivých nasycených a nenasycených mastných kyselin na růst a indukci buněčné smrti u linie lidských pankreatických β buněk linie NES2Y (cs)
- Comparison of the effect of individual saturated and unsaturated fatty acids on cell growth and death induction in the human pancreatic beta-cell line NES2Y (en)
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| skos:notation
| - RIV/00216208:11120/08:00000796!RIV09-MSM-11120___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11120/08:00000796
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Saturated fatty acids; Unsaturated fatty acids; Trans fatty acids; Cell growth; Cell death induction; Caspase-2; Pancreatic β-cells; NES2Y cells (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Kovář, Jan
- Fürstová, Vlasta
- Kopská, Tereza
- James, R. F.
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| http://linked.open...ain/vavai/riv/wos
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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