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| Description
| - Objective: We aim to demonstrate that low dose growth hormone (GH) administered in i.v. pulses every 3 h is able to normalize IGF-I levels in subjects with prolonged critical illness, after multiple trauma. We also ask whether it is possible to control glycaemia during such a treatment and how alanylglutamine (AG) supplementation influences plasma glutamine concentration. Methods: We used a prospective double-blind (group 1 vs. 2), randomized trial with an open-label control arm (group 3). Thirty multiple trauma patients (median age: 36, 42, 46 years) were randomized on day 4 after trauma to receive (group 1, n = 10) i.v. AG supplementation (0.3 g/kg day from day 4 till 17) and i.v. GH (0.05 mg/kg day divided into 8 boluses, maximum dose at 3 AM, administered on days 7-17) or AG and placebo (group 2, n = 10). Group 3 (n = 10) received isocaloric isonitrogenous (proteins 1.5 g/kg day) nutrition without AG. Glycaemia was controlled by i.v. insulin infusion according to a routine protocol. Results: GH tr
- Objective: We aim to demonstrate that low dose growth hormone (GH) administered in i.v. pulses every 3 h is able to normalize IGF-I levels in subjects with prolonged critical illness, after multiple trauma. We also ask whether it is possible to control glycaemia during such a treatment and how alanylglutamine (AG) supplementation influences plasma glutamine concentration. Methods: We used a prospective double-blind (group 1 vs. 2), randomized trial with an open-label control arm (group 3). Thirty multiple trauma patients (median age: 36, 42, 46 years) were randomized on day 4 after trauma to receive (group 1, n = 10) i.v. AG supplementation (0.3 g/kg day from day 4 till 17) and i.v. GH (0.05 mg/kg day divided into 8 boluses, maximum dose at 3 AM, administered on days 7-17) or AG and placebo (group 2, n = 10). Group 3 (n = 10) received isocaloric isonitrogenous (proteins 1.5 g/kg day) nutrition without AG. Glycaemia was controlled by i.v. insulin infusion according to a routine protocol. Results: GH tr (en)
- Účelem práce bylo prokázat, že malé dávky růstového hormonu (GH) podávané jako i.v. pulzy a 3 h jsou schopny normalizovat hladinu IGF-I u pacientů v prolongované fázi kritického onemocnění po polytraumatu. Též jsme se tázali, jak tato léčba ovlivní plazmatickozu hladuinu glutaminu a glykemickou kontrolu. Metody: Prospektivní (skupina 1 vs. 2),randomizovaná studie s otevřenou kontrolní větví (skupina 3). 30 pacientů s polytraumatem (median věku: 36, 42, 46 let) byli randomizováni 4. den po úraze k léčbě (sk. 1, n = 10) i.v. suplementací alanylglutaminu (0.3 g/kg den) a i.v. GH (0.05 mg/kg) nebo AG a placebem (sk. 2, n = 10). Skupina 3 (n = 10) byla léčena izokalorickou izonitrogenní (proteiny 1.5 g/kg den) výživou. Výsledky: Léčba GH způsobuila vzestup IGF-I (median ze 169 v den 4 k 493 ng/ml v den 17) a IGFBP-3 (z 2.4 k 3.2 mug/ml) a pokles IGFBP-1 (z 11.5 k 3.1 mug/ml), zatímco u skupin 2 a 3 byly hladiny těchto hormonů nezměněny. Ve skupině 1 bylo k dosažení kontroly glykém ie zapotřebí významn (cs)
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| Title
| - Frequent intravenous pulses of growth hormone together with alanylglutamine supplementation in prolonged critical illness after multiple trauma: Effects on glucose control, plasma IGF-I and glutamine
- Frequent intravenous pulses of growth hormone together with alanylglutamine supplementation in prolonged critical illness after multiple trauma: Effects on glucose control, plasma IGF-I and glutamine (en)
- Podání frekventních i.v. pulzů růstového hormonu spolu se suplementací glutaminu: vliv na glykemickou kontrolu, IGF-I a glutaminemii (cs)
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| skos:prefLabel
| - Frequent intravenous pulses of growth hormone together with alanylglutamine supplementation in prolonged critical illness after multiple trauma: Effects on glucose control, plasma IGF-I and glutamine
- Frequent intravenous pulses of growth hormone together with alanylglutamine supplementation in prolonged critical illness after multiple trauma: Effects on glucose control, plasma IGF-I and glutamine (en)
- Podání frekventních i.v. pulzů růstového hormonu spolu se suplementací glutaminu: vliv na glykemickou kontrolu, IGF-I a glutaminemii (cs)
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| skos:notation
| - RIV/00216208:11120/08:00000697!RIV09-MZ0-11120___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(NR8230), Z(MSM0021620814)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11120/08:00000697
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - growth hormone; protracted critical illness; insulin resistance; muscle wasting (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Growth Hormone & IGF Research
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Tůma, Petr
- Duška, František
- Waldauf, P.
- Fric, Michal
- Pachl, Jan
- Pažout, J.
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| http://linked.open...ain/vavai/riv/wos
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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