About: Expression of heat shock protein receptors on fibroblast-like synovial cells derived from rheumatoid arthritis-affected joints     Goto   Sponge   NotDistinct   Permalink

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Description
  • Vyšetřili jsme membránovou expresi indubilního proteinu Hsp70 a HSP receptorů jako jsou TLR2, TLR4, CD14, CD36, CD40 a CD91 využitím průtokové cytometrie na synoviálních buňkách odvozených ze synoviální tkáně 23 pacientů s revmatoidní artritidou (RA), kteří podstoupili synovektomii (cs)
  • We examined the membrane expression of inducible Hsp70 and HSP receptors like TLR2, TLR4, CD14, CD36, CD40 and CD91 on fibroblast-like synovial cells (SC) derived from synovial tissue in 23 patients with rheumatoid arthritis (RA), who underwent synovectomy by using flow cytometric analysis. For comparison, autologous skin fibroblasts (SF) derived from the operation wound were tested. Significantly higher Hsp70 expression was found on synovial cells than on skin fibroblasts (median SC 21.4% x SF 5.0%, P < 0.001). Both synovial cells and skin fibroblasts expressed high levels of cell surface CD91 (median SC 80.2% x SF 79.2%), however, no or low levels of CD14, CD40, TLR2, TLR4 and CD36. Further, we observed high co-expression of CD91 and Hsp70 on RA synovial cells (median 18.6%), while skin fibroblasts showed only background Hsp70 expression (median 3.9%, P < 0.001). Since we demonstrated the high prevalence of inducible Hsp70 in RA synovial fluids, we speculate that Hsp70 might be captured onto t
  • We examined the membrane expression of inducible Hsp70 and HSP receptors like TLR2, TLR4, CD14, CD36, CD40 and CD91 on fibroblast-like synovial cells (SC) derived from synovial tissue in 23 patients with rheumatoid arthritis (RA), who underwent synovectomy by using flow cytometric analysis. For comparison, autologous skin fibroblasts (SF) derived from the operation wound were tested. Significantly higher Hsp70 expression was found on synovial cells than on skin fibroblasts (median SC 21.4% x SF 5.0%, P < 0.001). Both synovial cells and skin fibroblasts expressed high levels of cell surface CD91 (median SC 80.2% x SF 79.2%), however, no or low levels of CD14, CD40, TLR2, TLR4 and CD36. Further, we observed high co-expression of CD91 and Hsp70 on RA synovial cells (median 18.6%), while skin fibroblasts showed only background Hsp70 expression (median 3.9%, P < 0.001). Since we demonstrated the high prevalence of inducible Hsp70 in RA synovial fluids, we speculate that Hsp70 might be captured onto t (en)
Title
  • Expression of heat shock protein receptors on fibroblast-like synovial cells derived from rheumatoid arthritis-affected joints
  • Expression of heat shock protein receptors on fibroblast-like synovial cells derived from rheumatoid arthritis-affected joints (en)
  • Exprese receptorů proteinů tepleného šoku na synoviálních buňkách z kloubů postižených revmatoidní artritidou (cs)
skos:prefLabel
  • Expression of heat shock protein receptors on fibroblast-like synovial cells derived from rheumatoid arthritis-affected joints
  • Expression of heat shock protein receptors on fibroblast-like synovial cells derived from rheumatoid arthritis-affected joints (en)
  • Exprese receptorů proteinů tepleného šoku na synoviálních buňkách z kloubů postižených revmatoidní artritidou (cs)
skos:notation
  • RIV/00216208:11120/08:00000540!RIV09-MZ0-11120___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • N, Z(MZ000064203), Z(MZ0FNM2005)
http://linked.open...iv/cisloPeriodika
  • 9
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 367424
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11120/08:00000540
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • CD91; inducible Hsp70; rheumatoid arthritis; synovial cells (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [38877FF12E0F]
http://linked.open...i/riv/nazevZdroje
  • Rheumatology International
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 28
http://linked.open...iv/tvurceVysledku
  • Popelka, Stanislav
  • Sosna, Antonín
  • Vavřincová, Pavla
  • Pech, Jan
  • Sedláčková, Lucie
  • Hromadníková, Ilona
  • Veigl, David
  • Nguyen, Thi Thu Hien
  • Zlacká, Denisa
http://linked.open...ain/vavai/riv/wos
  • 000256474800003
http://linked.open...n/vavai/riv/zamer
issn
  • 0172-8172
number of pages
http://localhost/t...ganizacniJednotka
  • 11120
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