About: Quantitation of minimal residual disease in patients with chronic lymphocytic leukemia using locked nucleic acid-modified, fluorescently labeled hybridization probes and real-time PCR technology

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About: Quantitation of minimal residual disease in patients with chronic lymphocytic leukemia using locked nucleic acid-modified, fluorescently labeled hybridization probes and real-time PCR technology Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Vyvinuli jsme kvantitativní molekulární přístup k monitorování minimální reziruální choroby (MRD) u pacientů s chronickou lymfocytární leukémií (CLL), který umožňuje detekci maligního klonu buněk s vyšší citlivostí než u jiných dostupných technik. Závěr: LNA-RNA-real-time PCRje efektivní způsob jak monitorovat MRD (cs) To address this issue in prospective studies, we have developed a quantitative molecular approach to monitor MRD in CLL, which allows the malignant clone to be traced with far higher sensitivity than possible with the techniques available currently. Conclusion: LNA-RNA-based quantitative real-time PCR is an effective approach for MRD monitoring with the potential for increased sensitivity compared with standard DNA-based assays used for molecular follow-up To address this issue in prospective studies, we have developed a quantitative molecular approach to monitor MRD in CLL, which allows the malignant clone to be traced with far higher sensitivity than possible with the techniques available currently. Conclusion: LNA-RNA-based quantitative real-time PCR is an effective approach for MRD monitoring with the potential for increased sensitivity compared with standard DNA-based assays used for molecular follow-up (en)
Title	Quantitation of minimal residual disease in patients with chronic lymphocytic leukemia using locked nucleic acid-modified, fluorescently labeled hybridization probes and real-time PCR technology Quantitation of minimal residual disease in patients with chronic lymphocytic leukemia using locked nucleic acid-modified, fluorescently labeled hybridization probes and real-time PCR technology (en) Výpočet minimálního zbytkového onemocnění u pacientů s chronickou lymfocytickou leukémii použitím uzavřené acid-modifikované, fluorescentně označené hybridní sondy a PCR technologií v reálném čase (cs)
skos:prefLabel	Quantitation of minimal residual disease in patients with chronic lymphocytic leukemia using locked nucleic acid-modified, fluorescently labeled hybridization probes and real-time PCR technology Quantitation of minimal residual disease in patients with chronic lymphocytic leukemia using locked nucleic acid-modified, fluorescently labeled hybridization probes and real-time PCR technology (en) Výpočet minimálního zbytkového onemocnění u pacientů s chronickou lymfocytickou leukémii použitím uzavřené acid-modifikované, fluorescentně označené hybridní sondy a PCR technologií v reálném čase (cs)
skos:notation	RIV/00216208:11120/07:00001037!RIV09-MSM-11120___
http://linked.open...avai/riv/aktivita	S V
http://linked.open...avai/riv/aktivity	S, V
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Kozák, Tomáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	446150
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/07:00001037
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	stem-cell transplantation; acute lymphoblastic-leukemia; gene mutational status; clinical-significance; prognostic-factors; CD38 expression; cll; progression; stage (en)
http://linked.open.../riv/klicoveSlovo	prognostic-factors progression stem-cell transplantation CD38 expression cll gene mutational status acute lymphoblastic-leukemia clinical-significance stage
http://linked.open...odStatuVydavatele	NZ - Nový Zéland
http://linked.open...ontrolniKodProRIV	[D057A8A0816C]
http://linked.open...i/riv/nazevZdroje	Molecular Diagnosis & Therapy
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	11
http://linked.open...iv/tvurceVysledku	Kozák, Tomáš Průcha, M. Žák, P. Hochová, I. Smolej, L. Peková, S. Bezdíčková, L. Tomsíková, L.
http://linked.open...ain/vavai/riv/wos	000251006600005
issn	1177-1062
number of pages	11 (xsd:int)
http://localhost/t...ganizacniJednotka	11120

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