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Description
  • Práce popisule prevenci diabetu typu 1 neměnnými NKT buňkami je nezávislá na periferní CD1d expresi (cs)
  • Invariant NKT (iNKT) cells can prevent diabetes by inhibiting the differentiation of anti-islet T cells. We recently showed that neither iNKT cell protection against diabetes nor iNKT cell inhibition of T cell differentiation in vitro requires cytokines such as IL-4, IL-10, IL-13, and TGF-beta. In contrast, cell-cell contacts were required for iNKT cell inhibition of T cell differentiation in vitro. The present study was designed to determine whether the CD1d molecule is involved in the inhibitory function of iNKT cells. Experiments were performed in vitro and in vivo, using cells lacking CD1d expression. The in vivo experiments used CD1d-deficient mice that were either reconstituted with iNKT cells or expressed a CD1d transgene exclusively in the thymus. Both mouse models had functional iNKT cells in the periphery, even though CD1d was not expressed in peripheral tissues. Surprisingly, both in vitro inhibition of T cell differentiation by iNKT cells and mouse protection against diabetes by iNKT cells
  • Invariant NKT (iNKT) cells can prevent diabetes by inhibiting the differentiation of anti-islet T cells. We recently showed that neither iNKT cell protection against diabetes nor iNKT cell inhibition of T cell differentiation in vitro requires cytokines such as IL-4, IL-10, IL-13, and TGF-beta. In contrast, cell-cell contacts were required for iNKT cell inhibition of T cell differentiation in vitro. The present study was designed to determine whether the CD1d molecule is involved in the inhibitory function of iNKT cells. Experiments were performed in vitro and in vivo, using cells lacking CD1d expression. The in vivo experiments used CD1d-deficient mice that were either reconstituted with iNKT cells or expressed a CD1d transgene exclusively in the thymus. Both mouse models had functional iNKT cells in the periphery, even though CD1d was not expressed in peripheral tissues. Surprisingly, both in vitro inhibition of T cell differentiation by iNKT cells and mouse protection against diabetes by iNKT cells (en)
Title
  • Prevention of type 1 diabetes by invariant NKT cells is independent of peripheral CD1d expression
  • Prevence diabetu typu 1 neměnnými NKT buňkami je nezávislá na periferní CD1d expresi (cs)
  • Prevention of type 1 diabetes by invariant NKT cells is independent of peripheral CD1d expression (en)
skos:prefLabel
  • Prevention of type 1 diabetes by invariant NKT cells is independent of peripheral CD1d expression
  • Prevence diabetu typu 1 neměnnými NKT buňkami je nezávislá na periferní CD1d expresi (cs)
  • Prevention of type 1 diabetes by invariant NKT cells is independent of peripheral CD1d expression (en)
skos:notation
  • RIV/00216208:11120/07:00000474!RIV08-MSM-11120___
http://linked.open.../vavai/riv/strany
  • 1332-1340
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • V
http://linked.open...iv/cisloPeriodika
  • 3
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 444035
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11120/07:00000474
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • killer T-cells; inkt cells; nod mouse; mice; recognition; activation; thymocytes; differentiation; lymphocytes; requirement (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [0F186E810BEB]
http://linked.open...i/riv/nazevZdroje
  • Journal of Immunology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 178
http://linked.open...iv/tvurceVysledku
  • Novák, Jan
  • Beaudoin, L.
  • Lehuen, A.
  • Griseri, T.
  • Bendelac, A.
  • Park, S. H.
  • Teyton, L.
issn
  • 0022-1767
number of pages
http://localhost/t...ganizacniJednotka
  • 11120
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