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Description
| - Cílem této studie bylo ukázat odlišný účinek pre a postsynaptických serotoninových-1A (5-HT1A) receptorů na psychóze podobné chování způsobené podáním antagonisty NMDA receptoru, dizocilpinu (MK-801). Samci potkana kmene Wistar obdrželi dvě dávky (0.025 mg/kg a 1 mg/kg) agonisty 5-HT1A receptoru 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin) a MK-801 (0,1 mg/kg a 0,3 mg/kg). Měřili jsme zpracování sensorimotorických informací pomocí testu prepulzní inhibice úlekové reakce (PPI) a lokomoční aktivitu potkanů. Našli jsme odlišný účinek nízké a vysoké dávky 5-HT1A agonisty na deficit v PPI a hyperlokomoci u habituovaných potkanů způsobené MK-801. Nízká dávka 8-OH-DPAT, která aktivuje přednostně presynaptické 5-HT1A receptory, zlepšila deficit v PPI a hyperlokomoci u habituovaných potkanů po podání MK-801 (0.1 mg/kg). Nicméně, vysoká dávka 8-OH-DPAT, která aktivuje oba pre- i postsynaptické 5-HT1A receptory, snížila PPI a zvýšila lokomoční aktivitu po podání nízké dávky MK-801. Podání 8-OH-DPAT samotné (cs)
- The purpose of the present study was to investigate the opposite effect of the pre- and postsynaptic serotonin-1A (5-HT1A) receptors on the psychotic-like behavior induced by a non-competitive antagonist of the NMDA receptor, dizocilpine (MK-801). Male Wistar rats received two doses (0.025 mg/kg and 1 mg/kg) of 5-HT1A receptor agonist 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino) tetralin) and/or MK-801 in two different doses, 0.1 mg/kg or 0.3 mg/kg. We measured sensorimotor gating by testing prepulse inhibition of acoustic startle response (PPI) and locomotor activity of rats. We found an opposite effect of the low and high 5-HT1A receptor agonist doses on MK-801 induced deficit in PPI and hyperlocomotion in habituated rats. The low dose of 8-OH-DPAT, which preferentially acts on presynaptic 5-HT1A receptors, restored the deficit in PPI and hyperlocomotion in MK-801 (0.1 mg/kg)-treated habituated rats. However, the high dose of 8-OH-DPAT, which activates both pre- and postsynaptic 5-HT1A receptors, decre
- The purpose of the present study was to investigate the opposite effect of the pre- and postsynaptic serotonin-1A (5-HT1A) receptors on the psychotic-like behavior induced by a non-competitive antagonist of the NMDA receptor, dizocilpine (MK-801). Male Wistar rats received two doses (0.025 mg/kg and 1 mg/kg) of 5-HT1A receptor agonist 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino) tetralin) and/or MK-801 in two different doses, 0.1 mg/kg or 0.3 mg/kg. We measured sensorimotor gating by testing prepulse inhibition of acoustic startle response (PPI) and locomotor activity of rats. We found an opposite effect of the low and high 5-HT1A receptor agonist doses on MK-801 induced deficit in PPI and hyperlocomotion in habituated rats. The low dose of 8-OH-DPAT, which preferentially acts on presynaptic 5-HT1A receptors, restored the deficit in PPI and hyperlocomotion in MK-801 (0.1 mg/kg)-treated habituated rats. However, the high dose of 8-OH-DPAT, which activates both pre- and postsynaptic 5-HT1A receptors, decre (en)
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Title
| - The opposite effect of a low and a high dose of serotonin-1A agonist on behavior induced by MK-801
- Opačný účinek nízké a vysoké dávky agonisty serotoninových-1A receptorů na chování indukované MK-801 (cs)
- The opposite effect of a low and a high dose of serotonin-1A agonist on behavior induced by MK-801 (en)
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skos:prefLabel
| - The opposite effect of a low and a high dose of serotonin-1A agonist on behavior induced by MK-801
- Opačný účinek nízké a vysoké dávky agonisty serotoninových-1A receptorů na chování indukované MK-801 (cs)
- The opposite effect of a low and a high dose of serotonin-1A agonist on behavior induced by MK-801 (en)
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skos:notation
| - RIV/00216208:11120/07:00000317!RIV08-MSM-11120___
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(1M0517), P(NL7684), Z(MSM0021620816)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11120/07:00000317
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - serotonin 5-HT1A receptors; 8-OH-DPAT; MK-801; PPI; locomotor activity; rats; schizophrenia (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Horáček, Jiří
- Páleníček, Tomáš
- Bubeníková-Valešová, Věra
- Votava, Martin
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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