About: Antibodies against light neurofilaments in multiple sclerosis patients

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Axonal damage in multiple sclerosis (MS) may be reflected by antibodies against axon-specific proteins - the light subunit of neurofilaments (NFL). The serum and cerebrospinal fluid obtained from 58 MS patients, 24 normal controls (CN), 49 control patients with miscellaneous diseases (CD) and 31 patients with neurodegenerative disorders (CDEG) were tested for both immunoglobulin G and M antibodies against NFL, using ELISA. Intrathecal IgG antibodies to NFL were elevated in MS patients compared to CD patients (p = 0.001) and were not related to clinical variables. No differences in IgM anti-NFL levels were found between the MS and CN/CD groups. IgM to NFL was higher in the CDEG group than in either the CD group or even the MS group (p < 0.0005). Intrathecal IgM or IgG antibodies to NFL are not useful surrogate markers for axonal damage or disease subtypes in MS. Axonal damage in multiple sclerosis (MS) may be reflected by antibodies against axon-specific proteins - the light subunit of neurofilaments (NFL). The serum and cerebrospinal fluid obtained from 58 MS patients, 24 normal controls (CN), 49 control patients with miscellaneous diseases (CD) and 31 patients with neurodegenerative disorders (CDEG) were tested for both immunoglobulin G and M antibodies against NFL, using ELISA. Intrathecal IgG antibodies to NFL were elevated in MS patients compared to CD patients (p = 0.001) and were not related to clinical variables. No differences in IgM anti-NFL levels were found between the MS and CN/CD groups. IgM to NFL was higher in the CDEG group than in either the CD group or even the MS group (p < 0.0005). Intrathecal IgM or IgG antibodies to NFL are not useful surrogate markers for axonal damage or disease subtypes in MS. (en)
Title	Antibodies against light neurofilaments in multiple sclerosis patients Antibodies against light neurofilaments in multiple sclerosis patients (en)
skos:prefLabel	Antibodies against light neurofilaments in multiple sclerosis patients Antibodies against light neurofilaments in multiple sclerosis patients (en)
skos:notation	RIV/00216208:11120/07:00000312!RIV10-MSM-11120___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(ME 492), Z(MSM0021620816)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Bartoš, Aleš Piťha, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	410118
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/07:00000312
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	antibody; axonal damage; cerebrospinal fluid; intrathecal synthesis; multiple sclerosis; neurofilament (en)
http://linked.open.../riv/klicoveSlovo	multiple sclerosis antibody neurofilament cerebrospinal fluid intrathecal synthesis axonal damage
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[EE26379C3C01]
http://linked.open...i/riv/nazevZdroje	Acta Neurologica Scandinavica
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	http://linked.opendata.cz/resource/domain/vavai/projekt/ME%20492
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	116
http://linked.open...iv/tvurceVysledku	Bartoš, Aleš Fialová, Lenka Piťha, Jiří Kukal, J. Malbohan, I. Soukupová, J.
http://linked.open...ain/vavai/riv/wos	000248730800005
http://linked.open...n/vavai/riv/zamer	Název: Patofyziologie neuropsychiatrických onemocnění a její klinické aplikace
issn	0001-6314
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	11120

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