| Attributes | Values |
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| rdf:type
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| Description
| - Sledovali sme efekt PPAR gamma, PPAR alpha a PPAR beta/delta agonistov na produkciu adipokinov ludskym podkoznym tukovym tkanivom. Kazdy z PPAR ligandov znizil sekreciu leptinu a interleukinu 6. PPAR alpha a PPAR beta/delta agonisti zvysili sekreciu HGF, zatial co PPAR beta/delta znizil produkciu angiogeninu a zvysil produkciu TIMP-1 (cs)
- he role of PPARs in the regulation of human adipose tissue secretome has received little attention despite its potential importance in the therapeutic actions of PPAR agonists. Here, we have investigated the effect of selective PPARgamma, PPARalpha, and PPARbeta/delta agonists on the production of adipokines by human subcutaneous adipose tissue. Antibody arrays were used to measure secreted factors in media from cultured adipose tissue explants. Sixteen proteins were produced in significant amounts. Activation of PPARs regulated the production of five proteins. Treatments with the three PPAR agonists decreased the secretion of leptin and interleukin-6. PPARalpha and beta/delta agonists markedly enhanced hepatocyte growth factor secretion whereas PPARbeta/delta down-regulated angiogenin and up-regulated TIMP-1 release. Hepatocyte growth factor, interleukin-6, and TIMP-1 are chiefly expressed in cells from the stromal vascular fraction whereas angiogenin is expressed in both adipocytes and cells from th
- he role of PPARs in the regulation of human adipose tissue secretome has received little attention despite its potential importance in the therapeutic actions of PPAR agonists. Here, we have investigated the effect of selective PPARgamma, PPARalpha, and PPARbeta/delta agonists on the production of adipokines by human subcutaneous adipose tissue. Antibody arrays were used to measure secreted factors in media from cultured adipose tissue explants. Sixteen proteins were produced in significant amounts. Activation of PPARs regulated the production of five proteins. Treatments with the three PPAR agonists decreased the secretion of leptin and interleukin-6. PPARalpha and beta/delta agonists markedly enhanced hepatocyte growth factor secretion whereas PPARbeta/delta down-regulated angiogenin and up-regulated TIMP-1 release. Hepatocyte growth factor, interleukin-6, and TIMP-1 are chiefly expressed in cells from the stromal vascular fraction whereas angiogenin is expressed in both adipocytes and cells from th (en)
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| Title
| - Profiling of adipokines secreted from human subcutaneous adipose tissue in response to PPAR agonists
- Profiling of adipokines secreted from human subcutaneous adipose tissue in response to PPAR agonists (en)
- Efekt PPAR agonistov na sekreciu adipokinov z ludskeho podkozneho tukoveho tkaniva (cs)
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| skos:prefLabel
| - Profiling of adipokines secreted from human subcutaneous adipose tissue in response to PPAR agonists
- Profiling of adipokines secreted from human subcutaneous adipose tissue in response to PPAR agonists (en)
- Efekt PPAR agonistov na sekreciu adipokinov z ludskeho podkozneho tukoveho tkaniva (cs)
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| skos:notation
| - RIV/00216208:11120/07:00000295!RIV08-MSM-11120___
|
| http://linked.open.../vavai/riv/strany
| |
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - P(NR8066), Z(MSM0021620814)
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| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
| |
| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11120/07:00000295
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - PPAR agonist; Cytokines; Antibody array; Secretome; Subcutaneous adipose tissue; Obesity (en)
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| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| - Biochemical and Biophysical Research Communications
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Štich, Vladimír
- Klimčáková, Eva
- Langin, D.
- Mazzucotelli, A.
- Moro, C.
- Viguerie, N.
- Galitzky, J.
- Lolmede, H.
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| http://linked.open...n/vavai/riv/zamer
| |
| issn
| |
| number of pages
| |
| http://localhost/t...ganizacniJednotka
| |
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