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| rdf:type
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| Description
| - The acute in vitro and in vivo effects of long-chain fatty acids (LCFAs) on the regulation of adrenergic lipolysis were investigated in human adipose tissue. The effect of a 2 h incubation, without or with LCFA (200 mumol/l), on basal and hormonally induced lipolysis was tested in vitro on isolated fat cells. The lipolytic response to epinephrine was enhanced by suppression of the antilipolytic alpha(2)-adrenergic effect. Then, healthy lean and obese male subjects performed a 45 min exercise bout at 50% of their heart rate reserve either after an overnight fast or 3 h after a high-fat meal (HFM: 95% fat, 5% carbohydrates). Subcutaneous adipose tissue lipolysis was measured by microdialysis in the presence or absence of an alpha-antagonist (phentolamine). In vivo, a HFM increased plasma levels of nonesterified fatty acids in lean and obese subjects. In both groups, the HFM did not alter hormonal responses to exercise. Under fasting conditions, the alpha(2)-adrenergic antilipolytic effect was more prono
- The acute in vitro and in vivo effects of long-chain fatty acids (LCFAs) on the regulation of adrenergic lipolysis were investigated in human adipose tissue. The effect of a 2 h incubation, without or with LCFA (200 mumol/l), on basal and hormonally induced lipolysis was tested in vitro on isolated fat cells. The lipolytic response to epinephrine was enhanced by suppression of the antilipolytic alpha(2)-adrenergic effect. Then, healthy lean and obese male subjects performed a 45 min exercise bout at 50% of their heart rate reserve either after an overnight fast or 3 h after a high-fat meal (HFM: 95% fat, 5% carbohydrates). Subcutaneous adipose tissue lipolysis was measured by microdialysis in the presence or absence of an alpha-antagonist (phentolamine). In vivo, a HFM increased plasma levels of nonesterified fatty acids in lean and obese subjects. In both groups, the HFM did not alter hormonal responses to exercise. Under fasting conditions, the alpha(2)-adrenergic antilipolytic effect was more prono (en)
- Cílem studie bylo sledovat vliv akutní expozice mastným kyselinám na regulaci adrenergní lipolýzy in vivi a in vitro. Lipolytický efekt byl zvýšem po 2 hod pre-inkubaci s mastnými kyselinami, zejmína díky potlačení alpha(2)-adrenergního anti-lipolytického efektu in vitro. In vivo byla seldována lipolýza během fyzické zátěže u doborovlníků na lačno nebo po požití vysokotučného pokrmu. Na lačno byl alpha(2)-adrenergní anti-lipolytický efekt patrný o obézních jedinců a po příjmu vysokotučného pokrmu byl zcela elimninován, což demonstruje účast mastných kyselin an regulaci lipolýzy (cs)
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| Title
| - Acute exposure to long-chain fatty acid impairs alpha2-adrenergic mediated antilipolysis in human adipose tissue
- Vliv akutní expozice mastným kyselinám s dlouhým řeztězcem na alfa2 adrenergní antilipolytický efekt v lidské tukové tkáni (cs)
- Acute exposure to long-chain fatty acid impairs alpha2-adrenergic mediated antilipolysis in human adipose tissue (en)
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| skos:prefLabel
| - Acute exposure to long-chain fatty acid impairs alpha2-adrenergic mediated antilipolysis in human adipose tissue
- Vliv akutní expozice mastným kyselinám s dlouhým řeztězcem na alfa2 adrenergní antilipolytický efekt v lidské tukové tkáni (cs)
- Acute exposure to long-chain fatty acid impairs alpha2-adrenergic mediated antilipolysis in human adipose tissue (en)
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| skos:notation
| - RIV/00216208:11120/07:00000285!RIV08-MSM-11120___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11120/07:00000285
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - free fatty acids; lipolysis (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Journal of Lipid Research
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Polák, Jan
- Štich, Vladimír
- Bajzová, Magda
- Hejnová, Jindřiška
- Berlan, M.
- Moro, C.
- Crampes, F.
- Lafontan, M.
- Marques, M. A.
- Bessiere, D.
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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