| Attributes | Values |
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| rdf:type
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| Description
| - Cílem studie bylo studovat úlohu thyroideálních hormonů na regulaci lipolýzy indukované ANP (atrialní natriuretický peptid) u pacientů s hyper a hypothyreózou, spolu s analýzou genové exprese HSL (hormone sensitive lipase), PDE3B (phosphodiesterase 3B), UCP2 (uncoupling protein 2), NPR-A (natriuretic peptide receptor type A) and 2AR (2-adrenergic receptor)v podkožní tukové tkáni. ANP- a isoprenalinem indukovaná lipolýza byla vyšší u hyperthyroidních pacientů.Genová exprese HSL byla vyšší u hyperthyroidních než u hypothyroidních subjektů. Závěr: thyroidní hormony se účastní regulace ANP- and isoprenalinem-indukované lipolýzy v lidské podkožní tukové tkáni (cs)
- Thyroid dysfunction is associated with several abnormalities in intermediary metabolism including impairment of lipolytic response to catecholamines in subcutaneous abdominal adipose tissue (SCAAT). Atrial natriuretic peptide (ANP) is a powerful lipolytic peptide, however, the role of ANP-mediated lipolysis in thyroid disease has not been elucidated. The aim of this study was to investigate the role of thyroid hormones in the regulation of ANPinduced lipolysis as well as in the gene expression of HSL (hormone sensitive lipase), PDE3B (phosphodiesterase 3B), UCP2 (uncoupling protein 2), NPR-A (natriuretic peptide receptor type A) and _2AR (_2-adrenergic receptor) in SCAAT of hyperthyroid and hypothyroid patients. Gene expression in SCAAT was studied in 13 hypothyroid and 11 hyperthyroid age matched women before and 2-4 months after the normalisation of their thyroid status. A microdialysis study was performed on a subset of 9 hyperthyroid and 10 hypothyroid subjects. ANP- and isoprenalineinduced lipol
- Thyroid dysfunction is associated with several abnormalities in intermediary metabolism including impairment of lipolytic response to catecholamines in subcutaneous abdominal adipose tissue (SCAAT). Atrial natriuretic peptide (ANP) is a powerful lipolytic peptide, however, the role of ANP-mediated lipolysis in thyroid disease has not been elucidated. The aim of this study was to investigate the role of thyroid hormones in the regulation of ANPinduced lipolysis as well as in the gene expression of HSL (hormone sensitive lipase), PDE3B (phosphodiesterase 3B), UCP2 (uncoupling protein 2), NPR-A (natriuretic peptide receptor type A) and _2AR (_2-adrenergic receptor) in SCAAT of hyperthyroid and hypothyroid patients. Gene expression in SCAAT was studied in 13 hypothyroid and 11 hyperthyroid age matched women before and 2-4 months after the normalisation of their thyroid status. A microdialysis study was performed on a subset of 9 hyperthyroid and 10 hypothyroid subjects. ANP- and isoprenalineinduced lipol (en)
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| Title
| - The atrial natriuretic peptide- and catecholamine-induced lipolysis and expression of related genes in adipose tissue in hypothyroid and hyperthyroid patients
- The atrial natriuretic peptide- and catecholamine-induced lipolysis and expression of related genes in adipose tissue in hypothyroid and hyperthyroid patients (en)
- Atriálním natriuretickým peptidem a katecholaminy indukovná lipolýza a genová exprese souvisejících genů v podkožní tukové tkáni u pacientlů s hypo a hyperthyreózou (cs)
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| skos:prefLabel
| - The atrial natriuretic peptide- and catecholamine-induced lipolysis and expression of related genes in adipose tissue in hypothyroid and hyperthyroid patients
- The atrial natriuretic peptide- and catecholamine-induced lipolysis and expression of related genes in adipose tissue in hypothyroid and hyperthyroid patients (en)
- Atriálním natriuretickým peptidem a katecholaminy indukovná lipolýza a genová exprese souvisejících genů v podkožní tukové tkáni u pacientlů s hypo a hyperthyreózou (cs)
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| skos:notation
| - RIV/00216208:11120/07:00000284!RIV08-MSM-11120___
|
| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(NB6832), P(NR8066), Z(MSM0021620814)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11120/07:00000284
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - thyroid dysfunction; lipolysis; atrial natriuretic peptide (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - American Journal of Physiology - Endocrinology and Metabolism
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Kováčová, Zuzana
- Polák, Jan
- Štich, Vladimír
- Bajzová, Magda
- Klimčáková, Eva
- Kováčiková, Michaela
- Vítková, Michaela
- Sotorník, Richard
- Berlan, M.
- Langin, D.
- Moro, C.
- Viguerie, N.
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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