| Attributes | Values |
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| rdf:type
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| Description
| - Type 1 diabetes with manifestation after 35 years of age is defined by CP <200 pmol/L and institution of insulin therapy within 6 months after diagnosis. Latent autoimmune diabetes mellitus in adults (LADA) manifesting after 35 years of age is defined by minimum 6 months after diagnosis without insulin therapy and C peptide (CP) >200 pmol/L and antiGAD > 50 ng/mL. We aimed to find a possible genetic discrimination among different types of autoimmune diabetes. To accomplish this goal, we analyzed DNA samples from 31 LADA patients, 75 patients with adult-onset type 1 diabetes mellitus, 188 type 1 diabetic children, and 153 healthy adult individuals. We studied five genetic loci on chromosomes 6, 11, 4, and 14: HLA DRB1 and DQB1 alleles, major histocompatibility complex (MHC) class I-related gene-A (MIC-A) microsatellite polymorphism, interleukin (IL)-18 single nucleotide polymorphism, the microsatellite polymorphism of nuclear factor kappa B gene (NF-kappaB1), and the single nucleotide polymorp
- Type 1 diabetes with manifestation after 35 years of age is defined by CP <200 pmol/L and institution of insulin therapy within 6 months after diagnosis. Latent autoimmune diabetes mellitus in adults (LADA) manifesting after 35 years of age is defined by minimum 6 months after diagnosis without insulin therapy and C peptide (CP) >200 pmol/L and antiGAD > 50 ng/mL. We aimed to find a possible genetic discrimination among different types of autoimmune diabetes. To accomplish this goal, we analyzed DNA samples from 31 LADA patients, 75 patients with adult-onset type 1 diabetes mellitus, 188 type 1 diabetic children, and 153 healthy adult individuals. We studied five genetic loci on chromosomes 6, 11, 4, and 14: HLA DRB1 and DQB1 alleles, major histocompatibility complex (MHC) class I-related gene-A (MIC-A) microsatellite polymorphism, interleukin (IL)-18 single nucleotide polymorphism, the microsatellite polymorphism of nuclear factor kappa B gene (NF-kappaB1), and the single nucleotide polymorp (en)
- Cílem této studie bylo geneticky rozlišit různé typy autoimunitního diabetes mellitus (DM): LADA, T1DM s nástupem v dospělosti a T1DM u dětí. Sledovali jsme 5 genetických lokusů: alely HLA DRB1 a DQB1, MIC-A mikrosatelitní polymorfismus, interleukin (IL)-18 SNP, mikrosatelitní polymorfismus genu pro NF-kappaB1a SNP v genu pro jeho inhibitor (NF-kappaBIA). Pro LADA diabetes jsou predispozičními alela HLA-DR3 (OR = 4.94, P < 0.0001) a genotyp AA NF-kappaBIA (OR = 2.68, P < 0.01). HLA DRB1*04 a HLA DQB1*0302 byly zjištěny jako rizikové faktory pro DM manifestovaný po 35. roce (OR = 10.47, P < 0.0001 a OR = 9.49, P < 0.0001). S tímto typem DM byla asociována také alela MIC-A5.1 (OR = 2.14, P < 0.01). LADA a T1DM u dospělých se lišily ve frekvenci polymorfismu -607 C/A promotoru IL-18 genu (P < 0.01). Lze tedy říci, že všechny podskupiny autoimunitního diabetes mají částečně odlišné imunogenetické predispozice. (cs)
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| Title
| - Autoimmune diabetes mellitus with adult onset and type 1 diabetes mellitus in children have different genetic predispositions
- Autoimunitní diabetes mellitus manifestovaný v dospělosti a typ 1 diabetes mellitus u dětí mají odlišné genetické predispozice (cs)
- Autoimmune diabetes mellitus with adult onset and type 1 diabetes mellitus in children have different genetic predispositions (en)
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| skos:prefLabel
| - Autoimmune diabetes mellitus with adult onset and type 1 diabetes mellitus in children have different genetic predispositions
- Autoimunitní diabetes mellitus manifestovaný v dospělosti a typ 1 diabetes mellitus u dětí mají odlišné genetické predispozice (cs)
- Autoimmune diabetes mellitus with adult onset and type 1 diabetes mellitus in children have different genetic predispositions (en)
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| skos:notation
| - RIV/00216208:11120/07:00000247!RIV08-MSM-11120___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11120/07:00000247
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - T1DM; LADA; IDDM; HLA; autoantibodies (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Annals of the New York Academy of Sciences
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...iv/tvurceVysledku
| - Kološtová, Katarína
- Pintérová, Daniela
- Černá, Marie
- Novota, Peter
- Průhová, Štěpánka
- Čejková, Pavlína
- Anděl, Michal
- Romžová, Marianna
- Trešlová, Ludmila
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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