About: Renal effects of HMG-CoA reductase inhibition in a rat model of chronic inhibition of nitric oxide synthesis

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About: Renal effects of HMG-CoA reductase inhibition in a rat model of chronic inhibition of nitric oxide synthesis Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In addition to their lipid-lowering effects, HMG-CoA reductase inhibitors (statins) induce a variety of pleiotropic actions that have been recently studied in the area of cardiovascular and renal protection. In the present studies we sought to determine whether statins retain beneficial effects in the experimental model of NO deficiency achieved by chronic administration of a pressor dose of L-arginine analogue N-nitro-L-arginine-methyl ester (L-NAME). METHODS: To address this issue, blood pressure (BP), renal function (GFR), and albuminuria were determined in rats treated for 4 weeks with L-NAME, L-NAME + atorvastatin (ATO), and in untreated controls. In addition, renal cortical protein expression of caveolin 1 (CAV1), vascular endothelial growth factor (VEGF), and activity of RhoA were also determined. RESULTS: L-NAME administration resulted in sustained elevation of BP, decreased GFR, and in higher albuminuria as compared to control animals. Co-administration of ATO with L-NAME normalized albuminur In addition to their lipid-lowering effects, HMG-CoA reductase inhibitors (statins) induce a variety of pleiotropic actions that have been recently studied in the area of cardiovascular and renal protection. In the present studies we sought to determine whether statins retain beneficial effects in the experimental model of NO deficiency achieved by chronic administration of a pressor dose of L-arginine analogue N-nitro-L-arginine-methyl ester (L-NAME). METHODS: To address this issue, blood pressure (BP), renal function (GFR), and albuminuria were determined in rats treated for 4 weeks with L-NAME, L-NAME + atorvastatin (ATO), and in untreated controls. In addition, renal cortical protein expression of caveolin 1 (CAV1), vascular endothelial growth factor (VEGF), and activity of RhoA were also determined. RESULTS: L-NAME administration resulted in sustained elevation of BP, decreased GFR, and in higher albuminuria as compared to control animals. Co-administration of ATO with L-NAME normalized albuminur (en)
Title	Renal effects of HMG-CoA reductase inhibition in a rat model of chronic inhibition of nitric oxide synthesis Renal effects of HMG-CoA reductase inhibition in a rat model of chronic inhibition of nitric oxide synthesis (en)
skos:prefLabel	Renal effects of HMG-CoA reductase inhibition in a rat model of chronic inhibition of nitric oxide synthesis Renal effects of HMG-CoA reductase inhibition in a rat model of chronic inhibition of nitric oxide synthesis (en)
skos:notation	RIV/00216208:11120/06:00002170!RIV11-MSM-11120___
http://linked.open...avai/riv/aktivita	S V
http://linked.open...avai/riv/aktivity	S, V
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Demová, Hana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	497199
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/06:00002170
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	atorvastatin; N-nitro-L-arginine-methyl ester; nitric oxide inhibition; hypertension; albuminuria; caveolin 1; vascular endothelial growth factor; RhoA (en)
http://linked.open.../riv/klicoveSlovo	atorvastatin vascular endothelial growth factor albuminuria RhoA hypertension - ischaemic heart disease - cardiac failure - vitamin D N-nitro-L-arginine-methyl ester caveolin 1 nitric oxide inhibition
http://linked.open...odStatuVydavatele	CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV	[17E4D5F66102]
http://linked.open...i/riv/nazevZdroje	Kidney & Blood Press Research
http://linked.open...in/vavai/riv/obor	FB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	29
http://linked.open...iv/tvurceVysledku	Demová, Hana Lecian, D.
http://linked.open...ain/vavai/riv/wos	000241163300001
issn	1420-4096
number of pages	9 (xsd:int)
http://localhost/t...ganizacniJednotka	11120

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