About: Genotoxic effect of Goeckerman regimen of psoriasis

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Goeckerman regimen (GR) of psoriasis includes daily dermal application of crude coal tar (CCT) and dermal exposure to UV-A and UV-B radiation. Observed group consisted of 23 patients with psoriasis treated by GR. Therapeutic ointment contained 5% of CCT. The level of psoriasis area and severity index was significantly decreased after GR (P < 0.001) and confirms high efficiency of GR. High levels of selected metabolites of pyrene and phenanthrene indicated high level of dermal penetration. We found significantly increased urinary mutagenicity in samples collected in the middle and in the end of GR (TA98+S9, P < 0.01; YG1041-S9, P < 0.001; YG1041+S9, P < 0.001). Significant increasing of chromosomal aberrations in peripheral lymphocytes (CA) in blood samples collected in the end of GR (P < 0.001) and consecutive decreasing of CA in 78th day after the end of GR has been observed. Almost all results indicated that the patients could be endangered by a peak genotoxic exposure. Nevertheless, Goeckerman regimen (GR) of psoriasis includes daily dermal application of crude coal tar (CCT) and dermal exposure to UV-A and UV-B radiation. Observed group consisted of 23 patients with psoriasis treated by GR. Therapeutic ointment contained 5% of CCT. The level of psoriasis area and severity index was significantly decreased after GR (P < 0.001) and confirms high efficiency of GR. High levels of selected metabolites of pyrene and phenanthrene indicated high level of dermal penetration. We found significantly increased urinary mutagenicity in samples collected in the middle and in the end of GR (TA98+S9, P < 0.01; YG1041-S9, P < 0.001; YG1041+S9, P < 0.001). Significant increasing of chromosomal aberrations in peripheral lymphocytes (CA) in blood samples collected in the end of GR (P < 0.001) and consecutive decreasing of CA in 78th day after the end of GR has been observed. Almost all results indicated that the patients could be endangered by a peak genotoxic exposure. Nevertheless, (en)
Title	Genotoxic effect of Goeckerman regimen of psoriasis Genotoxic effect of Goeckerman regimen of psoriasis (en)
skos:prefLabel	Genotoxic effect of Goeckerman regimen of psoriasis Genotoxic effect of Goeckerman regimen of psoriasis (en)
skos:notation	RIV/00216208:11120/06:00002141!RIV11-MSM-11120___
http://linked.open...avai/riv/aktivita	P V Z
http://linked.open...avai/riv/aktivity	P(NR8154), V, Z(MZ0FNHK2005)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Černá, Milena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	476911
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/06:00002141
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	psoriasis; Goeckerman regimen; polycyclic aromatic hydrocarbons; UV radiation (en)
http://linked.open.../riv/klicoveSlovo	UV radiation polycyclic aromatic hydrocarbons psoriasis Goeckerman regimen
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[E26CE9D14C3C]
http://linked.open...i/riv/nazevZdroje	Archives of Dermatological Research
http://linked.open...in/vavai/riv/obor	FO
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Health risk level evaluation of Goeckerman`s therapy (UV-B and coal tar) of psoriasis in adults
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	298
http://linked.open...iv/tvurceVysledku	Černá, Milena Fiala, Zdeněk
http://linked.open...ain/vavai/riv/wos	000240518700005
http://linked.open...n/vavai/riv/zamer	Nové diagnostické indikátory a léčebné postupy v závislosti na různých obdobích života s důrazem na stáří
issn	0340-3696
number of pages	9 (xsd:int)
http://localhost/t...ganizacniJednotka	11120

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