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  • Angiotensin-converting enzyme (ACE) inhibitors improve the prognosis in mild, moderate and severe heart failure, as well as preventing the onset of heart failure in patients with chronic asymptomatic left-ventricular dysfunction and in those with reduced ejection fraction after myocardial infarction (MI). Imidapril is a long-acting ACE inhibitor that is rapidly converted in the liver to its active metabolite, imidaprilat. Maximum plasma concentrations of imidapril and imidaprilat are achieved after 2 and 5-6 hours, respectively, with corresponding elimination half-lives of 1.1-2.5 and 10-19 hours. Imidapril is used in the treatment of hypertension, chronic heart failure, acute MI and diabetic nephropathy. In patients with mild-to-moderate chronic heart failure, imidapril 10 mg once-daily increased exercise time and physical working capacity, decreased plasma atrial natriuretic peptide and brain natriuretic peptide levels and reduced blood pressure. It also improved left ventricular ejection fraction,
  • Angiotensin-converting enzyme (ACE) inhibitors improve the prognosis in mild, moderate and severe heart failure, as well as preventing the onset of heart failure in patients with chronic asymptomatic left-ventricular dysfunction and in those with reduced ejection fraction after myocardial infarction (MI). Imidapril is a long-acting ACE inhibitor that is rapidly converted in the liver to its active metabolite, imidaprilat. Maximum plasma concentrations of imidapril and imidaprilat are achieved after 2 and 5-6 hours, respectively, with corresponding elimination half-lives of 1.1-2.5 and 10-19 hours. Imidapril is used in the treatment of hypertension, chronic heart failure, acute MI and diabetic nephropathy. In patients with mild-to-moderate chronic heart failure, imidapril 10 mg once-daily increased exercise time and physical working capacity, decreased plasma atrial natriuretic peptide and brain natriuretic peptide levels and reduced blood pressure. It also improved left ventricular ejection fraction, (en)
Title
  • Imidapril in heart failure
  • Imidapril in heart failure (en)
skos:prefLabel
  • Imidapril in heart failure
  • Imidapril in heart failure (en)
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  • RIV/00216208:11120/06:00002132!RIV11-MSM-11120___
http://linked.open...avai/riv/aktivita
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  • 478853
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  • RIV/00216208:11120/06:00002132
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  • imidapril; chronic heart failure; ACE inhibitor; left ventricular dysfunction; acute myocardial infarction; hypertension (en)
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  • GB - Spojené království Velké Británie a Severního Irska
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  • [8FD4783FF06D]
http://linked.open...i/riv/nazevZdroje
  • Journal of the Renin-Angiotensin-Aldosterone System
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  • 7
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  • Doležal, Tomáš
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  • 000241930000004
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  • 1470-3203
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  • 11120
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