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| Description
| - Objective: Proinflammatory cytokines IL-1ß, and IL-6 are synthesized in the brain, where they exert local regulatory functions. Our aim was to find out whether, along with the activation of hypothalamo-pituitary-adrenocortical (HPA) axis and prolactin (PRL), the acute systemic enhancement of IL-1ß affects its own production in the hypothalamus as well as that of IL-6. Method: Forty five minutes after a single i.p. administration of recombinant rat IL-1ß (5 μg/ kg) to male Long Evans rats we estimated the expression of IL-1ß and IL-6 mRNA in the hypothalamus by real time PCR, ACTH, corticosterone (CORT), and PRL by RIA Results: IL-1ß administration stimulated the expression of IL-1ß mRNA in the hypothalamus by 99 %, but not that of IL-6. It also significantly activated plasma levels of ACTH, PRL, CORT, and CORT production in adrenal gland. Conclusion: These results indicate that acute peripheral enhancement of IL-1ß may induce neuroendocrine changes also via the immediate activation of its own ex
- Objective: Proinflammatory cytokines IL-1ß, and IL-6 are synthesized in the brain, where they exert local regulatory functions. Our aim was to find out whether, along with the activation of hypothalamo-pituitary-adrenocortical (HPA) axis and prolactin (PRL), the acute systemic enhancement of IL-1ß affects its own production in the hypothalamus as well as that of IL-6. Method: Forty five minutes after a single i.p. administration of recombinant rat IL-1ß (5 μg/ kg) to male Long Evans rats we estimated the expression of IL-1ß and IL-6 mRNA in the hypothalamus by real time PCR, ACTH, corticosterone (CORT), and PRL by RIA Results: IL-1ß administration stimulated the expression of IL-1ß mRNA in the hypothalamus by 99 %, but not that of IL-6. It also significantly activated plasma levels of ACTH, PRL, CORT, and CORT production in adrenal gland. Conclusion: These results indicate that acute peripheral enhancement of IL-1ß may induce neuroendocrine changes also via the immediate activation of its own ex (en)
- Účel: Pro-zánětlivé cytokiny IL-1, a IL-6 jsou kromě imunitních buněk syntetizovány v mozku, kde mají lokální regulační funkce. Cílem naší studie bylo zjistit, zdali akutní systémové zvýšení IL-1 ovlivní vlastní produkci i produkci IL-6 v hypotalamu a ároveň aktivaci osy hypotalamus-adenohypofýza -nadledvinka a uvolnění prolaktinu. Metody: 45 minut po intraperitoneální aplikaci rekombinantního potkaního IL-1β (5μg/ kg) potkanům samcům kmene Long Evans jsme stanovili expresi mRNA pro IL-1β a IL-6 v hypotalamu metodou RT-PCR. V plasmě jsme stanovili hladiny ACTH, kortikosteronu a prolaktinu metodou RIA. Výsledky: Podání IL-1β stimulovalo expresi mRNA pro IL-1β v hypotalamu o 99%, ale neovlivnilo expresi mRNA pro IL-6. Podání IL-1β zvýšilo hladiny prolaktinu, ACTH a kortikosteronu v plasmě i produkci kortikosteronu v nadledvince. Závěr: Výsledky ukazují, že akutní periferní zvýšení IL-1β může vyvolat neuroendokrinní změny cestou okamžité aktivace vlastní exprese mRNA v (cs)
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| Title
| - Exogenous IL-1β induces its own expression, but not that of IL-6 in the hypothalamus and activates HPA Axis and prolactin release
- Endogenní IL-1beta indukuje v hypotalamu vlastní expresi, nepůsobí na expresi IL-6 a aktivuje HPA osu a uvolňování prolaktinu (cs)
- Exogenous IL-1β induces its own expression, but not that of IL-6 in the hypothalamus and activates HPA Axis and prolactin release (en)
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| skos:prefLabel
| - Exogenous IL-1β induces its own expression, but not that of IL-6 in the hypothalamus and activates HPA Axis and prolactin release
- Endogenní IL-1beta indukuje v hypotalamu vlastní expresi, nepůsobí na expresi IL-6 a aktivuje HPA osu a uvolňování prolaktinu (cs)
- Exogenous IL-1β induces its own expression, but not that of IL-6 in the hypothalamus and activates HPA Axis and prolactin release (en)
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| skos:notation
| - RIV/00216208:11120/06:00000920!RIV09-MSM-11120___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11120/06:00000920
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - IL-1 beta; IL-6 mRNA expression; HPA axis; hypothalamus (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Jurčovičová, Jana
- Škurlová, Martina
- Štofková, Andrea
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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