About: Acute pancreatitis: Proteinase-activated receptor-2 as Dr. Jekyll and Mr. Hyde     Goto   Sponge   NotDistinct   Permalink

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Description
  • %22Proteinase-activated%22 receptor-2 (PAR-2) is a G protein-coupled transmembrane receptor with seven transmembrane domains activated by trypsin. It has been shown in the pancreatic tissue that PAR-2 is involved in duct/acinary cells secretion, arterial tonus regulation and capillary liquid content turnover under physiological conditions. These above mentioned structures play an important role during the development of acute pancreatitis and are profoundly influenced by a high concentration of trypsin enzyme after its secretion into the interstitial tissue from the basolateral aspect of acinar cells. Among the other factors, it is the increase of interstitial trypsin concentration followed rapidly by PAR-2 action on pancreatic vascular smooth muscle cells that initiates ischemic changes in pancreatic parenchyma and that finally leads to necrosis of the pancreas. Consequent reperfusion perpetuates changes leading to the acute pancreatitis development. On the contrary, PAR-2 action on both exocrine a
  • %22Proteinase-activated%22 receptor-2 (PAR-2) is a G protein-coupled transmembrane receptor with seven transmembrane domains activated by trypsin. It has been shown in the pancreatic tissue that PAR-2 is involved in duct/acinary cells secretion, arterial tonus regulation and capillary liquid content turnover under physiological conditions. These above mentioned structures play an important role during the development of acute pancreatitis and are profoundly influenced by a high concentration of trypsin enzyme after its secretion into the interstitial tissue from the basolateral aspect of acinar cells. Among the other factors, it is the increase of interstitial trypsin concentration followed rapidly by PAR-2 action on pancreatic vascular smooth muscle cells that initiates ischemic changes in pancreatic parenchyma and that finally leads to necrosis of the pancreas. Consequent reperfusion perpetuates changes leading to the acute pancreatitis development. On the contrary, PAR-2 action on both exocrine a (en)
  • Autoři popisují akutní pankreatitidu a ukazují proteinázou aktivovaný receptor jako Dr. Jekylla a pan Hyda (cs)
Title
  • Acute pancreatitis: Proteinase-activated receptor-2 as Dr. Jekyll and Mr. Hyde
  • Acute pancreatitis: Proteinase-activated receptor-2 as Dr. Jekyll and Mr. Hyde (en)
  • Akutní pankreatitida: proteinázou aktivovaný receptor jako Dr. Jekyll a pan Hyde (cs)
skos:prefLabel
  • Acute pancreatitis: Proteinase-activated receptor-2 as Dr. Jekyll and Mr. Hyde
  • Acute pancreatitis: Proteinase-activated receptor-2 as Dr. Jekyll and Mr. Hyde (en)
  • Akutní pankreatitida: proteinázou aktivovaný receptor jako Dr. Jekyll a pan Hyde (cs)
skos:notation
  • RIV/00216208:11120/06:00000669!RIV09-MSM-11120___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • S, V
http://linked.open...iv/cisloPeriodika
  • 5
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 464106
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11120/06:00000669
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • PAR-2; acute pancreatitis; trypsin (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [770D15BA9C99]
http://linked.open...i/riv/nazevZdroje
  • Physiological Research
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 55
http://linked.open...iv/tvurceVysledku
  • Matěj, R.
  • Housa, Daniel
  • Olejár, T.
http://linked.open...ain/vavai/riv/wos
  • 000241910900001
issn
  • 0862-8408
number of pages
http://localhost/t...ganizacniJednotka
  • 11120
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