About: Streptokinase increases the sensitivity of colon cancer cells to chemotherapy by gemcitabine and cis-platine in vitro

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About: Streptokinase increases the sensitivity of colon cancer cells to chemotherapy by gemcitabine and cis-platine in vitro Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The aim was to determine the effect of fybrinolytic therapy by streptokinase on chemotherapy and radiation response in human colon cancer cells. The cells were treated with different concentrations of gemcitabine, cis-platine and streptokinase, at a single use or in combinations. Radiation was tested at a dose 0.5, 5 and 15 Gy in three different schedules. The chemotherapy showed higher cytotoxic effect in combination with streptokinase. On the other hand, the combination of chemotherapy with streptokinase and radiotherapy provide no improvement in sensitivity of cancer cells to treatment. The data suggest that fybrinolytic therapy could influence the effect of chemotherapy. The aim was to determine the effect of fybrinolytic therapy by streptokinase on chemotherapy and radiation response in human colon cancer cells. The cells were treated with different concentrations of gemcitabine, cis-platine and streptokinase, at a single use or in combinations. Radiation was tested at a dose 0.5, 5 and 15 Gy in three different schedules. The chemotherapy showed higher cytotoxic effect in combination with streptokinase. On the other hand, the combination of chemotherapy with streptokinase and radiotherapy provide no improvement in sensitivity of cancer cells to treatment. The data suggest that fybrinolytic therapy could influence the effect of chemotherapy. (en) Cílem práce bylo determinovat efekt fybrinolytické terapie v kombinaci s chemoterapií a radiotepií u lidského nádoru tlustého střeva. Buněčná kultura byla ošetřena gemcitabinem, cis-platinou a streptokinázou o ruzných koncentracích jednotlivě nebo v kombinacích. Radiace byla testována při dávkách 0,5; 5 a 15 Gy ve třech rozdílných ozařovacích programech. Výsledky studie poukázaly na vyšší cytotoxický efekt gemcitabinu v kombinaci s chemoterapií. Na druhé straně chemoterapie v kombinaci s radioterapií a streptokinázou nevykazuje zlepšení v citlivosti testovaných buněk na léčbu. Získaná data poukazují na možný vliv fybrinolytické terapie na chemoterapii. (cs)
Title	Streptokinase increases the sensitivity of colon cancer cells to chemotherapy by gemcitabine and cis-platine in vitro Streptokináza zvyšuje citlivost buněk nádoru tlustého střeva na chemoterapii gemcitabinem a cis-platinou in vitro (cs) Streptokinase increases the sensitivity of colon cancer cells to chemotherapy by gemcitabine and cis-platine in vitro (en)
skos:prefLabel	Streptokinase increases the sensitivity of colon cancer cells to chemotherapy by gemcitabine and cis-platine in vitro Streptokináza zvyšuje citlivost buněk nádoru tlustého střeva na chemoterapii gemcitabinem a cis-platinou in vitro (cs) Streptokinase increases the sensitivity of colon cancer cells to chemotherapy by gemcitabine and cis-platine in vitro (en)
skos:notation	RIV/00216208:11120/06:00000529!RIV09-AV0-11120___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Pintérová, Daniela Bobek, Vladimír Kološtová, Katarína
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	501814
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/06:00000529
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	chemotherapy; gemcitabine; radiation; streptokinase; colon cancer (en)
http://linked.open.../riv/klicoveSlovo	gemcitabine radiation chemotherapy colon cancer streptokinase
http://linked.open...odStatuVydavatele	IE - Irsko
http://linked.open...ontrolniKodProRIV	[0745DEAB78CE]
http://linked.open...i/riv/nazevZdroje	Cancer Letters
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	237
http://linked.open...iv/tvurceVysledku	Bobek, Vladimír Kološtová, Katarína Pintérová, Daniela Boubelík, M.
http://linked.open...ain/vavai/riv/wos	000238247300011
http://linked.open...n/vavai/riv/zamer	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů
issn	0304-3835
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	11120

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