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| Description
| - Úvod: Risperidon v antipsychotických dávkách vede k hyperprolaktinémii. Cílem této studie bylo objasnit, zdali také nízké dávky risperidonu (0,5-2 mg/denně) přidané k antidepresivům nebo anxiolytikám způsobují hyperprolaktinémii. Metody: Hladina prolaktinu byla měřena u 4 mužů (prům. věk 49,5+/-19,1 let) a 8 žen (prům. věk 31,3+/-8,2 let) hospitalizovaných pro depresivní či úzkostné poruchy. Pacienti byli léčeni risperidonem (medián denní dávky 1,25 mg). Risperidon byl použit jako augmentační léčba antidepresiv (n=8), anxiolytik (n=6) a thymostabilizérů (n=2) po dobu mediánu 15,5 dnů. Výsledky: 11 z 12 pacientů mělo hyperprolaktinémii. Medián plasmatické hladiny prolaktinu byl 1598 mIU/ml, 95% CI 1 040-2 661 mIU/ml. Byla zjištěna signifikatní korelace mezi denní dávkou risperidonu a plasmatickou hladinou prolaktinu (Spearmanovo R=0,655; p=0,02). U dvou žen se objevila galaktorrhea a u jedné amenorrhea. Závěr: I malé dávky risperidonu použité jako augmentace antidepresiv či benzodiazepinů jsou spojené (cs)
- OBJECTIVE: Risperidone in antipsychotic doses induces hyperprolactinemia. The aim of this study was to verify whether the same is true for low doses of risperidone (0.5-2 mg per day) added to antidepressants or anxiolytics. METHODS: Prolactin levels were measured in 4 men (mean age 49.5+/-19.1 years) and 8 women (mean age 31.3+/-8.2 years) inpatients with depressive and anxiety disorders who were treated with risperidone (median doses per day 1.25 mg) for median 15.5 days as an augmentation treatment to antidepressants (n=8), anxiolytics (n=6) and mood stabilizers (n=2). RESULTS: 11 of 12 patients had hyperprolactinemia. Median plasma prolactin level was 1598 mIU/ml, 95% CI 1 040-2 661 mIU/ml. Significant correlation between risperidone daily dose and plasma prolactin level (Spearman's R=0.655, p=0.02) was detected. Two women suffered from galactorrhea and one from amenorrhea. CONCLUSIONS: Even low doses of risperidone used as an augmentation to antidepressants or benzodiazepines are associated w
- OBJECTIVE: Risperidone in antipsychotic doses induces hyperprolactinemia. The aim of this study was to verify whether the same is true for low doses of risperidone (0.5-2 mg per day) added to antidepressants or anxiolytics. METHODS: Prolactin levels were measured in 4 men (mean age 49.5+/-19.1 years) and 8 women (mean age 31.3+/-8.2 years) inpatients with depressive and anxiety disorders who were treated with risperidone (median doses per day 1.25 mg) for median 15.5 days as an augmentation treatment to antidepressants (n=8), anxiolytics (n=6) and mood stabilizers (n=2). RESULTS: 11 of 12 patients had hyperprolactinemia. Median plasma prolactin level was 1598 mIU/ml, 95% CI 1 040-2 661 mIU/ml. Significant correlation between risperidone daily dose and plasma prolactin level (Spearman's R=0.655, p=0.02) was detected. Two women suffered from galactorrhea and one from amenorrhea. CONCLUSIONS: Even low doses of risperidone used as an augmentation to antidepressants or benzodiazepines are associated w (en)
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| Title
| - Low-dose risperidone augmentation of antidepressants or anxiolytics is associated with hyperprolactinemia
- Augmentace antidepresiv či anxiolytik nízkými dávkami risperidonu je spojena s hyperprolaktinemií (cs)
- Low-dose risperidone augmentation of antidepressants or anxiolytics is associated with hyperprolactinemia (en)
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| skos:prefLabel
| - Low-dose risperidone augmentation of antidepressants or anxiolytics is associated with hyperprolactinemia
- Augmentace antidepresiv či anxiolytik nízkými dávkami risperidonu je spojena s hyperprolaktinemií (cs)
- Low-dose risperidone augmentation of antidepressants or anxiolytics is associated with hyperprolactinemia (en)
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| skos:notation
| - RIV/00216208:11120/06:00000030!RIV07-MSM-11120___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11120/06:00000030
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - risperidone; prolactinemia; depression; anxiety; side effect; endocrinology (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Neuroendocrinology Letters
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Bareš, Martin
- Horáček, Jiří
- Kopeček, Miloslav
- Mohr, Pavel
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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