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| rdf:type
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| Description
| - Východiska: S cílem indikovat funkčně anatomický substrát kognitivní dysfunkce u schizofrenie jsme hodnotili vztah mezi klidovým metabolismem mozku a výkonem při Testu cesty (TMT). Nejprve jsme porovnali výkon v části A a B Testu cesty mezi pacienty trpícícími schizofrenií a kontrolními subjekty. Klidový metabolismus mozku byl vyšetřován 18FDG pozitronovou emisní tomografií (PET) jako indikátor synaptické denzity. Metody: Data z 18FDG PET byla analyzována pomocí SPM99 s částmi A a B Testu cesty jako kovariáty (pL0.001). Výsledky: Pacienti se schizofrenií (N=42) měli horší výkon v obou částech Testu cesty v porovnání s kontrolami (N=42). U subjektů se schizofrenií nepredikovala 18FDG PET výkon v části A Testu cesty (psychomotorická rychlost), ale predikovala ho pro část B Testu cesty (set-shifting a flexibilita). Vychytávání 18FDG v horním, středním a dolním frontálním gyru bilaterálně bylo asociováno s lepším výkonem v části B Testu cesty. Negativní kovariace mezi 18FDG vychytáváním a časem stráveným (cs)
- Objectives: With the aim to indicate the functional anatomical substrate of cognitive dysfunction in schizophrenia we evaluated the relationship between resting brain metabolism and performance on the Trail Making Test (TMT). As the prerequisite analysis we compared the performance in Part A and B of the TMT between schizophrenic patients and controls. Resting brain metabolism was investigated by 18FDG positron emission tomography (PET) as the probe for the relative regional synaptic strength and density. Methods: 18FDG PET data were analyzed by SPM99 with TMT A and B as the covariate (pL0.001). Results: Schizophrenic patients (N=42) had worse performance in both TMT A and B compared to controls (N=42). In schizophrenic subjects 18FDG PET did not predict the performance on Part A (psychomotor speed) but predicted that for Part B (set-shifting and flexibility) of the TMT. The 18FDG uptake in the superior, middle and inferior frontal gyruses bilaterally was associated with better performance in the TMT
- Objectives: With the aim to indicate the functional anatomical substrate of cognitive dysfunction in schizophrenia we evaluated the relationship between resting brain metabolism and performance on the Trail Making Test (TMT). As the prerequisite analysis we compared the performance in Part A and B of the TMT between schizophrenic patients and controls. Resting brain metabolism was investigated by 18FDG positron emission tomography (PET) as the probe for the relative regional synaptic strength and density. Methods: 18FDG PET data were analyzed by SPM99 with TMT A and B as the covariate (pL0.001). Results: Schizophrenic patients (N=42) had worse performance in both TMT A and B compared to controls (N=42). In schizophrenic subjects 18FDG PET did not predict the performance on Part A (psychomotor speed) but predicted that for Part B (set-shifting and flexibility) of the TMT. The 18FDG uptake in the superior, middle and inferior frontal gyruses bilaterally was associated with better performance in the TMT (en)
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| Title
| - Regional brain metabolism as the predictor of performance on the Trail Making Test in schizophrenia. A 18FDG PET covariation study
- Regionální metabolismus mozku jako prediktor výkonu na test cesty u schizofrenie. 18FDG PET kovariační studie (cs)
- Regional brain metabolism as the predictor of performance on the Trail Making Test in schizophrenia. A 18FDG PET covariation study (en)
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| skos:prefLabel
| - Regional brain metabolism as the predictor of performance on the Trail Making Test in schizophrenia. A 18FDG PET covariation study
- Regionální metabolismus mozku jako prediktor výkonu na test cesty u schizofrenie. 18FDG PET kovariační studie (cs)
- Regional brain metabolism as the predictor of performance on the Trail Making Test in schizophrenia. A 18FDG PET covariation study (en)
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| skos:notation
| - RIV/00216208:11120/06:00000024!RIV07-MSM-11120___
|
| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(1M0517), P(NR8792), Z(MZ0PCP2005)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11120/06:00000024
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Trail Making Test; Positron emission tomography (PET); 18FDG; schizophrenia; cognitive dysfunction (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Neuroendocrinology Letters
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Horáček, Jiří
- Höschl, Cyril
- Kopeček, Miloslav
- Páleníček, Tomáš
- Tišlerová, Barbora
- Klírová, Monika
- Španiel, Filip
- Novák, T.
- Dockery, Colleen
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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