About: The response-specific changes in EEG tomography (LORETA) after 1 and 4 weeks of treatment in patients with drug-resistant depression     Goto   Sponge   NotDistinct   Permalink

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  • Úvod: Předchozí studie u depresivních nemocných prokázaly, že depresivní symptomy jsou důsledkem dysfunkce limbických a frontálních oblastí, a pozitivní odpověď na léčbu je doprovázená recipročními změnami mozkového metabolismu v těchto oblastech. Cílem naší práce bylo přezkoumání rozdílů v distribuci mozkové elektrické aktivity nemocných s rezistentní depresivní poruchou v závislosti na čase (po 1 a 4 týdnech léčby) a odpovědi na léčbu. Metodika: 25 pacientů s rezistentní depresivní poruchou bylo vyšetřeno klinicky a pomocí EEG na začátku, po 1 týdnu a po 4 týdnech nové antidepresivní léčby. Proudová hustota elektrické aktivity (LORETA) byla určena ze spektrálně analyzovaných EEG dat a rozdíly jednotýdenních a čtyřtýdenních léčebných efektů u respondérů a nonrespondérů byly zobrazeny v podobě statistických parametrických map párových t-testů. Výsledky: Po jednom týdnu léčby došlo u respondérů ke zvýšení excitačních proudových hustot (beta pásmo) v oblasti zadního cingula a insuly, zatímco nonrespondé (cs)
  • Introduction: Previous studies of patients with unipolar depression have shown that depressive symptoms are caused by dysfunction of the limbic and frontal lobe regions and clinical response to treatment is associated with a reciprocal pattern of subcortical and limbic metabolic decreases and cortical increases. The aim of our study was to examine time-specific (1-week vs. baseline and 4-week vs. baseline) and response-specific (responders vs. non-responders) differences in brain electrical activities in patients with resistant depressive disorder. Method: The subjects were 25 inpatients with treatment resistant depression. EEG data and response to treatment were monitored at baseline and after 1 and 4 weeks on an antidepressant treatment. Low-resolution brain electromagnetic tomography (LORETA) was computed from spectrally analyzed EEG data, and differences between 1-week and 4-week treatment-induced changes in responders and non-responders were displayed as statistical parametric maps of voxel-by-vo
  • Introduction: Previous studies of patients with unipolar depression have shown that depressive symptoms are caused by dysfunction of the limbic and frontal lobe regions and clinical response to treatment is associated with a reciprocal pattern of subcortical and limbic metabolic decreases and cortical increases. The aim of our study was to examine time-specific (1-week vs. baseline and 4-week vs. baseline) and response-specific (responders vs. non-responders) differences in brain electrical activities in patients with resistant depressive disorder. Method: The subjects were 25 inpatients with treatment resistant depression. EEG data and response to treatment were monitored at baseline and after 1 and 4 weeks on an antidepressant treatment. Low-resolution brain electromagnetic tomography (LORETA) was computed from spectrally analyzed EEG data, and differences between 1-week and 4-week treatment-induced changes in responders and non-responders were displayed as statistical parametric maps of voxel-by-vo (en)
Title
  • The response-specific changes in EEG tomography (LORETA) after 1 and 4 weeks of treatment in patients with drug-resistant depression
  • The response-specific changes in EEG tomography (LORETA) after 1 and 4 weeks of treatment in patients with drug-resistant depression (en)
  • Změny EEG tomografie (LORETA) u pacientů s farmakorezistentní depresí po 1 a 4 týdnech léčby v závislosti na klinické odpovědi (cs)
skos:prefLabel
  • The response-specific changes in EEG tomography (LORETA) after 1 and 4 weeks of treatment in patients with drug-resistant depression
  • The response-specific changes in EEG tomography (LORETA) after 1 and 4 weeks of treatment in patients with drug-resistant depression (en)
  • Změny EEG tomografie (LORETA) u pacientů s farmakorezistentní depresí po 1 a 4 týdnech léčby v závislosti na klinické odpovědi (cs)
skos:notation
  • RIV/00216208:11120/06:00000008!RIV07-MSM-11120___
http://linked.open.../vavai/riv/strany
  • 71-79
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(1M0517)
http://linked.open...iv/cisloPeriodika
  • Suppl. 3
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 497409
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11120/06:00000008
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • treatment resistant depression; antidepressant therapy; EEG; low-resolution electromagnetic tomography (LORETA) (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [A29AC0486650]
http://linked.open...i/riv/nazevZdroje
  • Psychiatrie
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 10
http://linked.open...iv/tvurceVysledku
  • Bareš, Martin
  • Brunovský, Martin
  • Kopeček, Miloslav
  • Stopková, Pavla
  • Tišlerová, Barbora
  • Novák, T.
  • Krajča, V.
  • Závěšická, Lucie
  • Šóš, Petr
issn
  • 1211-7579
number of pages
http://localhost/t...ganizacniJednotka
  • 11120
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