About: Interleukin IL-18 gene promoter polymorphisms in adult patients with type 1 diabetes mellitus and latent autoimmune diabetes in adults     Goto   Sponge   NotDistinct   Permalink

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  • Interleukin-18 (IL-18) gene promoter polymorphism is known as a genetic risk factor for child type 1 diabetes mellitus development. The presentation describes analysis of SNPs at position -607 (C/A) and -137 (G/C) in the promoter region of IL-18 gene by sequence-specific PCR in patients withadult type 1 diabetes mellitus (T1DM) and latent autoimmune diabetes in adults (LADA), and in healthy controls. The results suggest that IL-18 gene promoter polymorphisms are not associated with adult type 1 diabetes or LADA susceptibility, and according to our findings genes involved in onset and progression of LADA and T1DM are probably different.
  • Interleukin-18 (IL-18) gene promoter polymorphism is known as a genetic risk factor for child type 1 diabetes mellitus development. The presentation describes analysis of SNPs at position -607 (C/A) and -137 (G/C) in the promoter region of IL-18 gene by sequence-specific PCR in patients withadult type 1 diabetes mellitus (T1DM) and latent autoimmune diabetes in adults (LADA), and in healthy controls. The results suggest that IL-18 gene promoter polymorphisms are not associated with adult type 1 diabetes or LADA susceptibility, and according to our findings genes involved in onset and progression of LADA and T1DM are probably different. (en)
  • Polymorfizmus promotoru genu pro interleukin IL-18 (IL-18) je známý jako genetický rizikový faktor pro rozvoj diabetes mellitus 1. typu dětí. Práce popisuje analýzu SNPs na pozici -607 (C/A) a -137 (G/C) vpromotorové oblasti genu IL-18 pomocí sekvenčně-specifické PCR u pacientů sdiabetes mellitus 1.typu dospělých (T1DM) a latentním autoimunitním diabetes u dospělých (LADA), a u zdravých kontrol. Výsledky poukazují, že polymorfizmy promotoru genu pro IL-18 nejsou asociované spredispozicí k diabetes 1.typu dospělých nebo k LADA, a na základě našich pozorování tedy geny zapojené do vzniku a progrese LADA a T1DM jsou pravděpodobně odlišné. (cs)
Title
  • Interleukin IL-18 gene promoter polymorphisms in adult patients with type 1 diabetes mellitus and latent autoimmune diabetes in adults
  • Interleukin IL-18 gene promoter polymorphisms in adult patients with type 1 diabetes mellitus and latent autoimmune diabetes in adults (en)
  • Polymorfizmy promotoru genu pro interleukin IL-18 u dospělých pacientů s diabetes mellitus 1. typu a latentním autoimunitním diabetes u dospělých (cs)
skos:prefLabel
  • Interleukin IL-18 gene promoter polymorphisms in adult patients with type 1 diabetes mellitus and latent autoimmune diabetes in adults
  • Interleukin IL-18 gene promoter polymorphisms in adult patients with type 1 diabetes mellitus and latent autoimmune diabetes in adults (en)
  • Polymorfizmy promotoru genu pro interleukin IL-18 u dospělých pacientů s diabetes mellitus 1. typu a latentním autoimunitním diabetes u dospělých (cs)
skos:notation
  • RIV/00216208:11120/05:00009656!RIV06-MZ0-11120___
http://linked.open.../vavai/riv/strany
  • 247;251
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(NB7432)
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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http://linked.open...iv/duvernostUdaju
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  • 525382
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11120/05:00009656
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Interleukin; IL-18; promoter; polymorphisms; adult; patients; diabetes; mellitus; latent; autoimmune; diabetes; adults (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [0D36C52443F5]
http://linked.open...i/riv/nazevZdroje
  • Immunology Letters
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 96
http://linked.open...iv/tvurceVysledku
  • Kološtová, Katarína
  • Novák, Jan
  • Pintérová, Daniela
  • Černá, Marie
  • Novota, Peter
  • Anděl, Michal
issn
  • 0165-2478
number of pages
http://localhost/t...ganizacniJednotka
  • 11120
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