About: Inhibition of T cell differentiation into effectors by NKT cells requires cell contacts

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	NKT cells are potent regulatory T cells that prevent the development of several autoimmune diseases. Analysis of NKT cell regulatory function in the NOD mouse has revealed that NKT cells inhibit the development of type I diabetes by impairing the differentiation of anti-islet T cells into Th1 effector cells. In the present study, we have performed in vitro and in vivo experiments to determine the respective role of cytokines and cell contacts in the blockade of T cell differentiation by NKT cells. These experiments reveal that cytokines such as IL-4, IL-10, IL-13, and TGF-beta, that have been involved in other functions of NKT cells, play only a minor role if any in the blockade of T cell differentiation by NKT cells. Diabetes is still prevented by NKT cells in the absence of functional IL-4, IL-10, IL-13, and TGF-beta. In contrast, we show for the first time that cell contacts are crucial for the immunoregulatory function of NKT cells. NKT cells are potent regulatory T cells that prevent the development of several autoimmune diseases. Analysis of NKT cell regulatory function in the NOD mouse has revealed that NKT cells inhibit the development of type I diabetes by impairing the differentiation of anti-islet T cells into Th1 effector cells. In the present study, we have performed in vitro and in vivo experiments to determine the respective role of cytokines and cell contacts in the blockade of T cell differentiation by NKT cells. These experiments reveal that cytokines such as IL-4, IL-10, IL-13, and TGF-beta, that have been involved in other functions of NKT cells, play only a minor role if any in the blockade of T cell differentiation by NKT cells. Diabetes is still prevented by NKT cells in the absence of functional IL-4, IL-10, IL-13, and TGF-beta. In contrast, we show for the first time that cell contacts are crucial for the immunoregulatory function of NKT cells. (en)
Title	Inhibition of T cell differentiation into effectors by NKT cells requires cell contacts Inhibition of T cell differentiation into effectors by NKT cells requires cell contacts (en)
skos:prefLabel	Inhibition of T cell differentiation into effectors by NKT cells requires cell contacts Inhibition of T cell differentiation into effectors by NKT cells requires cell contacts (en)
skos:notation	RIV/00216208:11120/05:00002343!RIV11-MSM-11120___
http://linked.open...avai/riv/aktivita	S
http://linked.open...avai/riv/aktivity	S
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Novák, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	525009
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/05:00002343
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Nonobese diabetic mice; experimental autoimmune encephalomyelitis; tumor immunosurveillance; monoclonal-antibody; systemic tolerance; in-vitro; activation; prevents; receptor; insulitis (en)
http://linked.open.../riv/klicoveSlovo	tumor immunosurveillance prevents activation experimental autoimmune encephalomyelitis receptor monoclonal-antibody in-vitro Nonobese diabetic mice insulitis systemic tolerance
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[D0F352F61AAF]
http://linked.open...i/riv/nazevZdroje	Journal of Immunology
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2005
http://linked.open...v/svazekPeriodika	174
http://linked.open...iv/tvurceVysledku	Novák, Jan Beaudoin, L. Griseri, T. Lehuen, A. S.
http://linked.open...ain/vavai/riv/wos	000226986700022
issn	0022-1767
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	11120

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