About: Prostacyclin versus citrate in continuous haemodiafiltration: An observational study in patients with high risk of bleeding

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About: Prostacyclin versus citrate in continuous haemodiafiltration: An observational study in patients with high risk of bleeding Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The efficacy and safety of prostacyclin (PGI(2)) and citrate (ACD) anticoagulation were observed and compared during continuous haemodiafiltration. Methods: Mechanically ventilated patients received either the PGI(2) analogue epoprostenol (group A, n = 17) in escalating doses of 4.5 - 10.0 ng center dot kg(-1) center dot min(-1) in combination with heparin (6 IU center dot kg(-1) center dot h(-1)) or 2.2% ACD ( group B, n = 15). Blood flow was set to match the circuit-filling volume per unit time equal to the intravascular half-life of PGI(2). Results: Median filter lifetimes were 26 h (interquartile range 16 - 37) in group A ( 39 filters) and 36.5 h ( interquartile range 23 - 50) in group B (56 filters; p < 0.01). In group A, 4 patients (23.5%, p < 0.05) had the dose reduced due to hypotension. The final mean dose of PGI(2) was 8.7 +/- 2.4 ng center dot kg(-1) center dot min(-1). Four patients in group A (23.5%, p < 0.05) were switched to ACD due to a decrease in platelet count. No bleeding The efficacy and safety of prostacyclin (PGI(2)) and citrate (ACD) anticoagulation were observed and compared during continuous haemodiafiltration. Methods: Mechanically ventilated patients received either the PGI(2) analogue epoprostenol (group A, n = 17) in escalating doses of 4.5 - 10.0 ng center dot kg(-1) center dot min(-1) in combination with heparin (6 IU center dot kg(-1) center dot h(-1)) or 2.2% ACD ( group B, n = 15). Blood flow was set to match the circuit-filling volume per unit time equal to the intravascular half-life of PGI(2). Results: Median filter lifetimes were 26 h (interquartile range 16 - 37) in group A ( 39 filters) and 36.5 h ( interquartile range 23 - 50) in group B (56 filters; p < 0.01). In group A, 4 patients (23.5%, p < 0.05) had the dose reduced due to hypotension. The final mean dose of PGI(2) was 8.7 +/- 2.4 ng center dot kg(-1) center dot min(-1). Four patients in group A (23.5%, p < 0.05) were switched to ACD due to a decrease in platelet count. No bleeding (en)
Title	Prostacyclin versus citrate in continuous haemodiafiltration: An observational study in patients with high risk of bleeding Prostacyclin versus citrate in continuous haemodiafiltration: An observational study in patients with high risk of bleeding (en)
skos:prefLabel	Prostacyclin versus citrate in continuous haemodiafiltration: An observational study in patients with high risk of bleeding Prostacyclin versus citrate in continuous haemodiafiltration: An observational study in patients with high risk of bleeding (en)
skos:notation	RIV/00216208:11120/05:00002337!RIV11-MSM-11120___
http://linked.open...avai/riv/aktivita	N
http://linked.open...avai/riv/aktivity	N
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Pachl, J.
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	539336
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/05:00002337
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	acute renal failure; renal replacement therapy; haemodiafiltration; prostacyclin; citrate (en)
http://linked.open.../riv/klicoveSlovo	prostacyclin renal replacement therapy citrate acute renal failure haemodiafiltration
http://linked.open...odStatuVydavatele	CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV	[EFEE1360C38C]
http://linked.open...i/riv/nazevZdroje	Blood Purification
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2005
http://linked.open...v/svazekPeriodika	23
http://linked.open...iv/tvurceVysledku	Balík, Martin Waldauf, Petr Pachl, Jan Plášil, Petr
issn	0253-5068
number of pages	5 (xsd:int)
http://localhost/t...ganizacniJednotka	11120

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