About: Modulation of murine cellular immune response and cytokine production by salivary gland lysate of three sand fly species

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Saliva of sand flies (Diptera: Phlebotominae) plays an important role in transmission of Leishmania parasites by modulating host immune response. However, because of the different protein compositions of saliva, the immunomodulatory effects may vary among sand fly species. We have therefore analysed the immunomodulation effects of salivary gland lysate (SGL) of three different sand flies. Spleen cells from BALB/c mice were incubated with SGL of Phlebotomus papatasi, P. sergenti or Lutzomyia longipalpis. Concanavalin A-stimulated lymphocyte proliferation was suppressed with SGLs of all three sand fly species and all SGL doses tested. SGL also markedly inhibited IFN-gamma production in all intervals tested (reduced up to 31%) and to a lesser degree impaired production of the IL-2 and IL-4. Despite some species-specific differences in the intensity of immunomodulatory effects, saliva of all sand fly species modulated cell proliferation as well as cytokine production in a similar way. Saliva of sand flies (Diptera: Phlebotominae) plays an important role in transmission of Leishmania parasites by modulating host immune response. However, because of the different protein compositions of saliva, the immunomodulatory effects may vary among sand fly species. We have therefore analysed the immunomodulation effects of salivary gland lysate (SGL) of three different sand flies. Spleen cells from BALB/c mice were incubated with SGL of Phlebotomus papatasi, P. sergenti or Lutzomyia longipalpis. Concanavalin A-stimulated lymphocyte proliferation was suppressed with SGLs of all three sand fly species and all SGL doses tested. SGL also markedly inhibited IFN-gamma production in all intervals tested (reduced up to 31%) and to a lesser degree impaired production of the IL-2 and IL-4. Despite some species-specific differences in the intensity of immunomodulatory effects, saliva of all sand fly species modulated cell proliferation as well as cytokine production in a similar way. (en)
Title	Modulation of murine cellular immune response and cytokine production by salivary gland lysate of three sand fly species Modulation of murine cellular immune response and cytokine production by salivary gland lysate of three sand fly species (en)
skos:prefLabel	Modulation of murine cellular immune response and cytokine production by salivary gland lysate of three sand fly species Modulation of murine cellular immune response and cytokine production by salivary gland lysate of three sand fly species (en)
skos:notation	RIV/00216208:11120/05:00002112!RIV10-MSM-11120___
http://linked.open...avai/riv/aktivita	P V Z
http://linked.open...avai/riv/aktivity	P(GA310/03/1381), V, Z(AV0Z5052915), Z(MSM 113100004), Z(MSM0021620828)
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Lipoldová, Marie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	530974
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/05:00002112
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cytokine production; Lutzomyia; Phlebotomus (en)
http://linked.open.../riv/klicoveSlovo	Phlebotomus Lutzomyia cytokine production
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[8E6C076E5EC8]
http://linked.open...i/riv/nazevZdroje	Parasite Immunology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Genetic analysis of immune response II.
http://linked.open...UplatneniVysledku	2005
http://linked.open...v/svazekPeriodika	27
http://linked.open...iv/tvurceVysledku	Volf, P. Lipoldová, Marie Rohousová, I.
http://linked.open...ain/vavai/riv/wos	000232850200006
http://linked.open...n/vavai/riv/zamer	Ekologické procesy v evoluci modelových skupin organismů Regulace a signální cesty uplatňující se v genové expresi, imunitě, onkogenezi, replikaci virů, tvorbě buněčných struktur, chování buněk, vývoji a oplození http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20113100004
issn	0141-9838
number of pages	5 (xsd:int)
http://localhost/t...ganizacniJednotka	11120

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