About: Genetic determinants of folate status in Central Bohemia

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Although several genetic factors have been implicated as determinants of blood folate concentration in various populations, their effect on folate status in the Czech population has not yet been examined. We explored whether blood folate concentrations in healthy Czech population are associated with polymorphisms in 5,10-methylenetetrahydrofolate reductase (MTHFR), Folate hydrolase 1 (FOLH1), reduced folate carrier (RFC), and folate receptor (FOLR1) genes. In a cross-sectional study of 591 control subjects we determined genotypes by PCR-RFLP or ARMS-PCR methods, and plasma and erythrocyte folates by MEIA. The effect of different genotypes on folate status was examined by non-parametric tests and by regression analysis. The prevalence of the MTHFR 677C > T, MTHFR 1298A > C, FOLH1 1561C > T, RFC 80G > A and FOLR1 480G > C variant alleles was 0.34, 0.33, 0.05, 0.44 and 0.00, respectively. Only the MTHFR 677C > T variant was significantly associated with plasma folate concentrations (med Although several genetic factors have been implicated as determinants of blood folate concentration in various populations, their effect on folate status in the Czech population has not yet been examined. We explored whether blood folate concentrations in healthy Czech population are associated with polymorphisms in 5,10-methylenetetrahydrofolate reductase (MTHFR), Folate hydrolase 1 (FOLH1), reduced folate carrier (RFC), and folate receptor (FOLR1) genes. In a cross-sectional study of 591 control subjects we determined genotypes by PCR-RFLP or ARMS-PCR methods, and plasma and erythrocyte folates by MEIA. The effect of different genotypes on folate status was examined by non-parametric tests and by regression analysis. The prevalence of the MTHFR 677C > T, MTHFR 1298A > C, FOLH1 1561C > T, RFC 80G > A and FOLR1 480G > C variant alleles was 0.34, 0.33, 0.05, 0.44 and 0.00, respectively. Only the MTHFR 677C > T variant was significantly associated with plasma folate concentrations (med (en) Autoři popisují genetické vymezení stavu folátů ve středních Čechách (cs)
Title	Genetic determinants of folate status in Central Bohemia Genetic determinants of folate status in Central Bohemia (en) Genetické vymezení stavu folátů ve středních Čechách (cs)
skos:prefLabel	Genetic determinants of folate status in Central Bohemia Genetic determinants of folate status in Central Bohemia (en) Genetické vymezení stavu folátů ve středních Čechách (cs)
skos:notation	RIV/00216208:11120/05:00001336!RIV09-MZ0-11120___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(NA6497), P(NM6548), Z(MSM 111100003)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Anděl, M.
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	522541
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/05:00001336
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	folates; folate hydrolase 1; reduced folate carrier; 5,10-methylenetetrahydrofolate reductase; polymorphism (en)
http://linked.open.../riv/klicoveSlovo	5 folates polymorphism reduced folate carrier folate hydrolase 1 10-methylenetetrahydrofolate reductase
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[D22B0F6E5616]
http://linked.open...i/riv/nazevZdroje	Physiological Research
http://linked.open...in/vavai/riv/obor	FB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Hyperhomocysteinemia and its significance causing cardiovascular and thromboembolic complications in patients from intensive care units. Complication of pregnancy associated with hyperhomocysteinemia: the role of genetic variants in the development of neural tube defects, orofacial clefts, and preeclampsia
http://linked.open...UplatneniVysledku	2005
http://linked.open...v/svazekPeriodika	54
http://linked.open...iv/tvurceVysledku	Anděl, Michal Zvárová, J. Janošíková, B. Kožich, V. Veselá, K. Pavlíková, M. Hyánek, J.
http://linked.open...ain/vavai/riv/wos	000230306700005
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20111100003
issn	0862-8408
number of pages	9 (xsd:int)
http://localhost/t...ganizacniJednotka	11120

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